Influence of parainfluenza-1 respiratory tract viral infection on endothelin receptor-effector systems in mouse and rat tracheal smooth muscle

P.G. Knott, Peter Henry, A.S. Mcwilliam, Paul Rigby, Lynette Fernandes, Roy Goldie

Research output: Contribution to journalArticlepeer-review

12 Citations (Web of Science)

Abstract

1 In this study we have compared the effects of parainfluenza-l respiratory tract viral infection on the density and function of ET(A) and ET(B) receptors in rat and mouse tracheal airway smooth muscle.2 The bronchoconstrictor effect of inhaled methacholine was significantly enhanced in virus-infected rats, at both 4 and 12 days post-inoculation. That is, the concentration of methacholine causing an increase in resistance of 100% (PC100 methacholine) was significantly lower in virus-infected animals at both 4 and 12 days post-inoculation (n=6-8; P
Original languageEnglish
Pages (from-to)291-298
JournalBritish Journal of Pharmacology
Volume119
DOIs
Publication statusPublished - 1996

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