Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model

H. Hou, K. Zheng, G. Wang, S. Ikegawa, Minghao Zheng, X. Gao, J. Qin, H. Teng, Q. Jiang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

© 2015 Huacheng Hou et al. Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair. However, several disadvantages of this method have been reported, such as transplanted cartilage degeneration and the lack of a connection between the grafted and adjacent cartilage tissues. To evaluate the effect of intra-articular administration of trichostatin A (TSA) on AOT, we conducted a case control study in a rabbit model. International Cartilage Repair Society (ICRS) macroscopic scores, the modified O'Driscoll histology scores, and real-time PCR were utilized to evaluate the results. At 4 weeks, both macroscopic and histological assessments showed that there was no significant difference between the TSA and control groups. However, the mean macroscopic and histological scores for the TSA-treated group were significantly higher than the scores for the control group at 12 weeks. TSA was shown to directly reduce collagen type II (COL2), aggrecan, matrix metalloproteinase (MMP), and a disintegrin and metalloproteinase domain with thrombospondin motifs 5 (ADAMTS-5) expression and to simultaneously repress the upregulation of MMP-3, MMP-9, and MMP-13 levels induced by interleukin 1β (IL-1β) in chondrocytes. In conclusion, TSA protects AOT grafts from degeneration, which may provide a benefit in the repair of articular cartilage injury.
Original languageEnglish
Pages (from-to)1-8
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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