Tinnitus is a phantom perception often caused by cochlear trauma and the development of abnormal activity along the central auditory pathway. Electrical stimulation of frontostriatal areas, nucleus accumbens and prefrontal cortex (PFC), was found to change the firing rates of medial geniculate nucleus (MGN) in Wistar rats.After noise exposure, MGN burst firing rates were found to be significantly decreased and PFC stimulation elicited larger inhibitory responses in MGN neurons. These studies provide the first evidence for a frontostriatal circuit that modulates auditory thalamus which can become altered after cochlear damage.
|Qualification||Doctor of Philosophy|
|Award date||23 Sep 2019|
|Publication status||Unpublished - 2019|