Influence of frontostriatal circuitry on the auditory thalamus

Research output: ThesisDoctoral Thesis

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Tinnitus is a phantom perception often caused by cochlear trauma and the development of abnormal activity along the central auditory pathway. Electrical stimulation of frontostriatal areas, nucleus accumbens and prefrontal cortex (PFC), was found to change the firing rates of medial geniculate nucleus (MGN) in Wistar rats.After noise exposure, MGN burst firing rates were found to be significantly decreased and PFC stimulation elicited larger inhibitory responses in MGN neurons. These studies provide the first evidence for a frontostriatal circuit that modulates auditory thalamus which can become altered after cochlear damage.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Mulders, Wilhelmina, Supervisor
  • Robertson, Donald, Supervisor
Thesis sponsors
Award date23 Sep 2019
Publication statusUnpublished - 2019


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