Influence of frontostriatal circuitry on the auditory thalamus

Kristin Barry

doi:10.26182/5dafd2ed28fae

Influence of frontostriatal circuitry on the auditory thalamus

Kristin Barry

School of Human Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Tinnitus is a phantom perception often caused by cochlear trauma and the development of abnormal activity along the central auditory pathway. Electrical stimulation of frontostriatal areas, nucleus accumbens and prefrontal cortex (PFC), was found to change the firing rates of medial geniculate nucleus (MGN) in Wistar rats.After noise exposure, MGN burst firing rates were found to be significantly decreased and PFC stimulation elicited larger inhibitory responses in MGN neurons. These studies provide the first evidence for a frontostriatal circuit that modulates auditory thalamus which can become altered after cochlear damage.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Mulders, Wilhelmina, Supervisor Robertson, Donald, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	23 Sept 2019
DOIs	https://doi.org/10.26182/5dafd2ed28fae
Publication status	Unpublished - 2019

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10.26182/5dafd2ed28fae

TH19 245 THESIS - DOCTOR OF PHILOSOPHY - BARRY Kristin Marie - 2019
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Cite this

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abstract = "Tinnitus is a phantom perception often caused by cochlear trauma and the development of abnormal activity along the central auditory pathway. Electrical stimulation of frontostriatal areas, nucleus accumbens and prefrontal cortex (PFC), was found to change the firing rates of medial geniculate nucleus (MGN) in Wistar rats.After noise exposure, MGN burst firing rates were found to be significantly decreased and PFC stimulation elicited larger inhibitory responses in MGN neurons. These studies provide the first evidence for a frontostriatal circuit that modulates auditory thalamus which can become altered after cochlear damage. ",

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AB - Tinnitus is a phantom perception often caused by cochlear trauma and the development of abnormal activity along the central auditory pathway. Electrical stimulation of frontostriatal areas, nucleus accumbens and prefrontal cortex (PFC), was found to change the firing rates of medial geniculate nucleus (MGN) in Wistar rats.After noise exposure, MGN burst firing rates were found to be significantly decreased and PFC stimulation elicited larger inhibitory responses in MGN neurons. These studies provide the first evidence for a frontostriatal circuit that modulates auditory thalamus which can become altered after cochlear damage.

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KW - neuroscience

KW - nucleus accumbens

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Influence of frontostriatal circuitry on the auditory thalamus

Abstract

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