Abstract
The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.
| Original language | English |
|---|---|
| Journal | Australian Endodontic Journal |
| DOIs | |
| Publication status | E-pub ahead of print - 3 Jul 2019 |
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Influence of different irrigants on substance P and IL-8 expression for single visit root canal treatment in acute irreversible pulpitis. / Evangelin, J.; Sherwood, I. Anand; Abbott, Paul V.; Uthandakalaipandian, Ramesh; Velu, Vijay.
In: Australian Endodontic Journal, 03.07.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Influence of different irrigants on substance P and IL-8 expression for single visit root canal treatment in acute irreversible pulpitis
AU - Evangelin, J.
AU - Sherwood, I. Anand
AU - Abbott, Paul V.
AU - Uthandakalaipandian, Ramesh
AU - Velu, Vijay
PY - 2019/7/3
Y1 - 2019/7/3
N2 - The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.
AB - The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.
KW - Dexamethasone
KW - IL-8
KW - ketorolac tromethamine
KW - post-operative pain
KW - root canal irrigants
KW - substance P
UR - http://www.scopus.com/inward/record.url?scp=85068609132&partnerID=8YFLogxK
U2 - 10.1111/aej.12340
DO - 10.1111/aej.12340
M3 - Article
JO - Australian Endodontic Newsletter
JF - Australian Endodontic Newsletter
SN - 1747-4477
ER -