Influence of different irrigants on substance P and IL-8 expression for single visit root canal treatment in acute irreversible pulpitis

J. Evangelin, I. Anand Sherwood, Paul V. Abbott, Ramesh Uthandakalaipandian, Vijay Velu

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.

Original languageEnglish
JournalAustralian Endodontic Journal
DOIs
Publication statusE-pub ahead of print - 3 Jul 2019

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Pulpitis
Dental Pulp Cavity
Substance P
Ketorolac Tromethamine
Interleukin-8
Dexamethasone
Sodium Hypochlorite
Pain
Root Canal Irrigants
Bicuspid
Tooth
Therapeutics
Enzyme-Linked Immunosorbent Assay

Cite this

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title = "Influence of different irrigants on substance P and IL-8 expression for single visit root canal treatment in acute irreversible pulpitis",
abstract = "The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3{\%} sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.",
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year = "2019",
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Influence of different irrigants on substance P and IL-8 expression for single visit root canal treatment in acute irreversible pulpitis. / Evangelin, J.; Sherwood, I. Anand; Abbott, Paul V.; Uthandakalaipandian, Ramesh; Velu, Vijay.

In: Australian Endodontic Journal, 03.07.2019.

Research output: Contribution to journalArticle

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