Influence of anti-inflammatory irrigant on substance P expression for single-visit root canal treatment of teeth with irreversible pulpitis

Lavanya Bamini, I. Anand Sherwood, Paul V. Abbott, Ramesh Uthandakalaipandian, Vijay Velu

Research output: Contribution to journalArticle

Abstract

One of the main objectives of root canal treatment is to alleviate the pain associated with irreversibly inflamed pulps. However, some patients may have moderate to severe pain following treatment. The aim of this study was to compare and assess the effect of ketorolac tromethamine on substance P expression in the pulp and periapical tissues when used as a root canal irrigant for single-visit root canal treatment in teeth with irreversible pulpitis. Thirty-six patients were randomly allotted to three irrigant groups – saline (n = 14), 3% sodium hypochlorite (n = 11) and ketorolac tromethamine (n = 11). Pulp blood samples (S1) were collected on gaining access to the pulp, and periapical blood samples (S2) were collected after root canal preparation. Quantification of substance P was done by ELISA test. The ketorolac tromethamine group had greater reduction in substance P expression (S2). Post-operative pain levels were not significantly influenced by the different root canal irrigants.

Original languageEnglish
JournalAustralian Endodontic Journal
DOIs
Publication statusE-pub ahead of print - 3 Jul 2019

Fingerprint

Ketorolac Tromethamine
Pulpitis
Root Canal Irrigants
Dental Pulp Cavity
Substance P
Tooth
Anti-Inflammatory Agents
Pain
Periapical Tissue
Root Canal Preparation
Sodium Hypochlorite
Therapeutics
Enzyme-Linked Immunosorbent Assay

Cite this

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title = "Influence of anti-inflammatory irrigant on substance P expression for single-visit root canal treatment of teeth with irreversible pulpitis",
abstract = "One of the main objectives of root canal treatment is to alleviate the pain associated with irreversibly inflamed pulps. However, some patients may have moderate to severe pain following treatment. The aim of this study was to compare and assess the effect of ketorolac tromethamine on substance P expression in the pulp and periapical tissues when used as a root canal irrigant for single-visit root canal treatment in teeth with irreversible pulpitis. Thirty-six patients were randomly allotted to three irrigant groups – saline (n = 14), 3{\%} sodium hypochlorite (n = 11) and ketorolac tromethamine (n = 11). Pulp blood samples (S1) were collected on gaining access to the pulp, and periapical blood samples (S2) were collected after root canal preparation. Quantification of substance P was done by ELISA test. The ketorolac tromethamine group had greater reduction in substance P expression (S2). Post-operative pain levels were not significantly influenced by the different root canal irrigants.",
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Influence of anti-inflammatory irrigant on substance P expression for single-visit root canal treatment of teeth with irreversible pulpitis. / Bamini, Lavanya; Anand Sherwood, I.; Abbott, Paul V.; Uthandakalaipandian, Ramesh; Velu, Vijay.

In: Australian Endodontic Journal, 03.07.2019.

Research output: Contribution to journalArticle

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