Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes

L. Cubo; A.G. Quiroga; J. Zhang; Donald Thomas; A. Carnero; C. Navarro-Ranninger; Susan Berners-Price

doi:10.1039/b819301k

Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes

L. Cubo, A.G. Quiroga, J. Zhang, Donald Thomas, A. Carnero, C. Navarro-Ranninger, Susan Berners-Price

School of Molecular Sciences

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40 Citations (Web of Science)

Abstract

Three 15N-labelled trans-Pt(II) amine complexes with isopropylamine (15N-ipa), methylamine (15N-ma) and dimethylamine (15N-dma) have been prepared and characterized. 2D [1H,15N] HSQC NMR spectroscopy was used to obtain the rate and equilibrium constants for the aquation of trans-[PtCl2(15N-ipa)(15N-ma)] (15N-1), trans-[PtCl2(15N-dma)(15N-ma)] (15N-2) and trans-[PtCl2(15N-dma)(15N-ipa)] (15N-3) in 100 mM NaClO4 solutions at 298 K. New 15N shift ranges for H2N–PtII–N and HN–PtII–N groups are reported. Formation of the diaqua complex was not observed for 3 and accounted for

Original language	English
Pages (from-to)	3457-3466
Journal	Dalton Transactions
Volume	2009
Issue number	18
DOIs	https://doi.org/10.1039/b819301k
Publication status	Published - 2009

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title = "Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes",

abstract = "Three 15N-labelled trans-Pt(II) amine complexes with isopropylamine (15N-ipa), methylamine (15N-ma) and dimethylamine (15N-dma) have been prepared and characterized. 2D [1H,15N] HSQC NMR spectroscopy was used to obtain the rate and equilibrium constants for the aquation of trans-[PtCl2(15N-ipa)(15N-ma)] (15N-1), trans-[PtCl2(15N-dma)(15N-ma)] (15N-2) and trans-[PtCl2(15N-dma)(15N-ipa)] (15N-3) in 100 mM NaClO4 solutions at 298 K. New 15N shift ranges for H2N–PtII–N and HN–PtII–N groups are reported. Formation of the diaqua complex was not observed for 3 and accounted for",

author = "L. Cubo and A.G. Quiroga and J. Zhang and Donald Thomas and A. Carnero and C. Navarro-Ranninger and Susan Berners-Price",

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TY - JOUR

T1 - Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes

AU - Cubo, L.

AU - Quiroga, A.G.

AU - Zhang, J.

AU - Thomas, Donald

AU - Carnero, A.

AU - Navarro-Ranninger, C.

AU - Berners-Price, Susan

PY - 2009

Y1 - 2009

N2 - Three 15N-labelled trans-Pt(II) amine complexes with isopropylamine (15N-ipa), methylamine (15N-ma) and dimethylamine (15N-dma) have been prepared and characterized. 2D [1H,15N] HSQC NMR spectroscopy was used to obtain the rate and equilibrium constants for the aquation of trans-[PtCl2(15N-ipa)(15N-ma)] (15N-1), trans-[PtCl2(15N-dma)(15N-ma)] (15N-2) and trans-[PtCl2(15N-dma)(15N-ipa)] (15N-3) in 100 mM NaClO4 solutions at 298 K. New 15N shift ranges for H2N–PtII–N and HN–PtII–N groups are reported. Formation of the diaqua complex was not observed for 3 and accounted for

AB - Three 15N-labelled trans-Pt(II) amine complexes with isopropylamine (15N-ipa), methylamine (15N-ma) and dimethylamine (15N-dma) have been prepared and characterized. 2D [1H,15N] HSQC NMR spectroscopy was used to obtain the rate and equilibrium constants for the aquation of trans-[PtCl2(15N-ipa)(15N-ma)] (15N-1), trans-[PtCl2(15N-dma)(15N-ma)] (15N-2) and trans-[PtCl2(15N-dma)(15N-ipa)] (15N-3) in 100 mM NaClO4 solutions at 298 K. New 15N shift ranges for H2N–PtII–N and HN–PtII–N groups are reported. Formation of the diaqua complex was not observed for 3 and accounted for

U2 - 10.1039/b819301k

DO - 10.1039/b819301k

M3 - Article

C2 - 19381408

SN - 1477-9226

VL - 2009

SP - 3457

EP - 3466

JO - Dalton Transactions

JF - Dalton Transactions

IS - 18

ER -

Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes

Abstract

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