Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head

G. Li, Q. Zheng, Euphemie Landao-Bassonga, Tak Sum Cheng, Nathan Pavlos, Y. Ma, C. Zhang, Minghao Zheng

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

© 2015 Elsevier Inc. Introduction: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. Methods: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. Results: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. Conclusions: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.
Original languageEnglish
Pages (from-to)91-97
JournalBone
Volume77
DOIs
Publication statusPublished - 2015

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Bone Remodeling
Thigh
Bone and Bones
Bone Cysts
Homeostasis
Cancellous Bone
Joints
Weight-Bearing
Cysts

Cite this

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title = "Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head",
abstract = "{\circledC} 2015 Elsevier Inc. Introduction: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. Methods: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. Results: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. Conclusions: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.",
author = "G. Li and Q. Zheng and Euphemie Landao-Bassonga and Cheng, {Tak Sum} and Nathan Pavlos and Y. Ma and C. Zhang and Minghao Zheng",
year = "2015",
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language = "English",
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Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head. / Li, G.; Zheng, Q.; Landao-Bassonga, Euphemie; Cheng, Tak Sum; Pavlos, Nathan; Ma, Y.; Zhang, C.; Zheng, Minghao.

In: Bone, Vol. 77, 2015, p. 91-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head

AU - Li, G.

AU - Zheng, Q.

AU - Landao-Bassonga, Euphemie

AU - Cheng, Tak Sum

AU - Pavlos, Nathan

AU - Ma, Y.

AU - Zhang, C.

AU - Zheng, Minghao

PY - 2015

Y1 - 2015

N2 - © 2015 Elsevier Inc. Introduction: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. Methods: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. Results: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. Conclusions: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.

AB - © 2015 Elsevier Inc. Introduction: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. Methods: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. Results: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. Conclusions: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.

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DO - 10.1016/j.bone.2015.04.019

M3 - Article

VL - 77

SP - 91

EP - 97

JO - Bone

JF - Bone

SN - 8756-3282

ER -