The research investigated neural hyperactivity in the inferior collculus of normal hearing guinea pigs and those that underwent acoustic trauma. Three main findings were found, 1) all response types in the inferior collculus (with the possible exception of onset neurons) were hyperactive after acoustic trauma, 2) paraflocculus removal resulted In increased spontaneous firing rates In acoustic trauma animals only and 3) stimulation of the paraflocculus resulted In both excitation and inhibition in sub-populations of inferior collculus neurons. The results increase understanding of the relationship between neural plasticity and the pathology of tinnitus and its modulation by intrinsic neural pathways.
|Qualification||Doctor of Philosophy|
|Award date||25 Aug 2016|
|Publication status||Unpublished - 2016|