[Truncated abstract] The incidence of acute stroke is diminishing in Australia. However population ageing will lead to an increase in the overall burden of mortality and disability associated with stroke. Despite the availability of stroke unit care and thrombolytic therapy there is an urgent need for improved acute stroke therapies. Vascular dysfunction, oxidative stress and inflammation are thought to contribute to the aetiology and pathophysiology of acute ischaemic stroke. Statin and angiotensin receptor antagonist therapy (which are effective in the secondary prevention of stroke) are known to reduce inflammation and improve vascular function and may be beneficial in the acute treatment of ischaemic stroke. However the efficacy and safety of earlier initiation of medical therapies treatment (aiming to limit cerebral injury) is uncertain. The studies for this thesis were conducted to test the hypotheses that inflammation and disordered vascular function are important contributors to the aetiology and pathophysiology of acute ischaemic stroke, and that treatment aiming to diminish inflammation and improve vascular function would improve clinical outcomes among acute stroke survivors.
|Qualification||Doctor of Philosophy|
|Publication status||Unpublished - 2011|