TY - JOUR
T1 - Infectious Prophylaxis in Pediatric Oncology and Stem Cell Transplantation
AU - Yeoh, Daniel Kheng Choong
AU - Ryan, Anne. L.
AU - Blyth, Christopher
PY - 2015
Y1 - 2015
N2 - The advances in the survival of children with cancer and following stem cell transplant have, in part, been due to more effective infection prevention strategies. Morbidity and mortality following bacterial, viral and fungal infection remain significant necessitating further refinement of existing prophylactic strategies. Novel antiviral agents, newer and better tolerated antifungal drugs, antibiotic bacterial prophylaxis and adoptive immunotherapy in high-risk groups are potential approaches for which supportive evidence is emerging. Questions remain as to the optimal approach to infectious prophylaxis using currently available agents. There is a clear need for further directed paediatric research in this area.
AB - The advances in the survival of children with cancer and following stem cell transplant have, in part, been due to more effective infection prevention strategies. Morbidity and mortality following bacterial, viral and fungal infection remain significant necessitating further refinement of existing prophylactic strategies. Novel antiviral agents, newer and better tolerated antifungal drugs, antibiotic bacterial prophylaxis and adoptive immunotherapy in high-risk groups are potential approaches for which supportive evidence is emerging. Questions remain as to the optimal approach to infectious prophylaxis using currently available agents. There is a clear need for further directed paediatric research in this area.
U2 - 10.1007/s40124-015-0076-x
DO - 10.1007/s40124-015-0076-x
M3 - Review article
VL - 3
SP - 160
EP - 169
JO - Current Pediatrics Reports
JF - Current Pediatrics Reports
IS - 2
ER -
