Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms

Lloyd D'Orsogna, Heleen van den Heuvel, Cees van Kooten, Sebastiaan Heidt, Frans H.J. Claas

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Transplant recipients can be sensitized against allo-HLA antigens by previous transplantation, blood transfusion, or pregnancy. While there is growing awareness that multiple components of the immune system can act as effectors of the alloresponse, the role of infectious pathogen exposure in triggering sensitization and allograft rejection has remained a matter of much debate. Here, we describe that exposure to pathogens may enhance the immune response to allogeneic HLA antigens via different pathways. The potential role of allo-HLA cross-reactivity of virus-specific memory T cells, activation of innate immunity leading to a more efficient induction of the adaptive alloimmune response by antigen-presenting cells, and bystander activation of existing memory B cell activation will be discussed in this review.

Original languageEnglish
Pages (from-to)631-641
Number of pages11
JournalImmunogenetics
Volume69
Issue number8-9
DOIs
Publication statusPublished - 1 Aug 2017

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HLA Antigens
Antigen-Presenting Cells
Innate Immunity
Blood Transfusion
Allografts
Immune System
B-Lymphocytes
Transplantation
Viruses
T-Lymphocytes
Pregnancy
Transplant Recipients

Cite this

D'Orsogna, Lloyd ; van den Heuvel, Heleen ; van Kooten, Cees ; Heidt, Sebastiaan ; Claas, Frans H.J. / Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms. In: Immunogenetics. 2017 ; Vol. 69, No. 8-9. pp. 631-641.
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Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms. / D'Orsogna, Lloyd; van den Heuvel, Heleen; van Kooten, Cees; Heidt, Sebastiaan; Claas, Frans H.J.

In: Immunogenetics, Vol. 69, No. 8-9, 01.08.2017, p. 631-641.

Research output: Contribution to journalReview article

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T1 - Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms

AU - D'Orsogna, Lloyd

AU - van den Heuvel, Heleen

AU - van Kooten, Cees

AU - Heidt, Sebastiaan

AU - Claas, Frans H.J.

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AB - Transplant recipients can be sensitized against allo-HLA antigens by previous transplantation, blood transfusion, or pregnancy. While there is growing awareness that multiple components of the immune system can act as effectors of the alloresponse, the role of infectious pathogen exposure in triggering sensitization and allograft rejection has remained a matter of much debate. Here, we describe that exposure to pathogens may enhance the immune response to allogeneic HLA antigens via different pathways. The potential role of allo-HLA cross-reactivity of virus-specific memory T cells, activation of innate immunity leading to a more efficient induction of the adaptive alloimmune response by antigen-presenting cells, and bystander activation of existing memory B cell activation will be discussed in this review.

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