Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)

Tony Scalzo; S. Elliott; J. Cox; J. Gardner; D.J. Moss; A. Suhrbier

Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)

Tony Scalzo, S. Elliott, J. Cox, J. Gardner, D.J. Moss, A. Suhrbier

Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

Original language	English
Pages (from-to)	1306-1309
Journal	Journal of Virology
Volume	69
Publication status	Published - 1995

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title = "Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)",

abstract = "The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.",

author = "Tony Scalzo and S. Elliott and J. Cox and J. Gardner and D.J. Moss and A. Suhrbier",

year = "1995",

language = "English",

volume = "69",

pages = "1306--1309",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)

AU - Scalzo, Tony

AU - Elliott, S.

AU - Cox, J.

AU - Gardner, J.

AU - Moss, D.J.

AU - Suhrbier, A.

PY - 1995

Y1 - 1995

N2 - The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

AB - The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

M3 - Article

VL - 69

SP - 1306

EP - 1309

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

ER -

Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)

Abstract

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