Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720)

Tony Scalzo, S. Elliott, J. Cox, J. Gardner, D.J. Moss, A. Suhrbier

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.
Original languageEnglish
Pages (from-to)1306-1309
JournalJournal of Virology
Volume69
Publication statusPublished - 1995

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