TY - JOUR
T1 - Indocyanine Green-Glycogen Conjugates for Near-Infrared-Triggered Photothermal Cancer Therapy
AU - Shirinichi, Farbod
AU - Karkera, Chetna
AU - Ibrahim, Tarek
AU - Khan, Hayat
AU - Clemons, Tristan
AU - Senejani, Alireza G.
AU - Sun, Hao
PY - 2023/12
Y1 - 2023/12
N2 - Photothermal reagents sensitive to near-infrared (NIR) light are promising imaging agents and therapeutics for anticancer applications because of the deep tissue penetration of NIR light, allowing for spatiotemporal control over the therapeutic activity, with minimal damage to normal tissues. Herein, a new class of NIR-sensitive biopolymer-based nanoparticles is presented by covalently conjugating indocyanine green (ICG) onto the surface of naturally occurring glycogen nanoparticles. The resulting ICG-glycogen conjugates exhibit a markedly enhanced aqueous stability in comparison to free ICG molecules. Furthermore, an efficient light-to-heat conversion is enabled by ICG-glycogen conjugates, as evidenced by the elevated temperatures of their aqueous solutions upon exposure to NIR light. Critically, ICG-glycogen conjugates are capable of cell internalization, and under NIR irradiation the effective eradication of breast cancer cells, demonstrating their potential in photothermal therapy for cancer.
AB - Photothermal reagents sensitive to near-infrared (NIR) light are promising imaging agents and therapeutics for anticancer applications because of the deep tissue penetration of NIR light, allowing for spatiotemporal control over the therapeutic activity, with minimal damage to normal tissues. Herein, a new class of NIR-sensitive biopolymer-based nanoparticles is presented by covalently conjugating indocyanine green (ICG) onto the surface of naturally occurring glycogen nanoparticles. The resulting ICG-glycogen conjugates exhibit a markedly enhanced aqueous stability in comparison to free ICG molecules. Furthermore, an efficient light-to-heat conversion is enabled by ICG-glycogen conjugates, as evidenced by the elevated temperatures of their aqueous solutions upon exposure to NIR light. Critically, ICG-glycogen conjugates are capable of cell internalization, and under NIR irradiation the effective eradication of breast cancer cells, demonstrating their potential in photothermal therapy for cancer.
KW - biopolymers
KW - glycogen
KW - indocyanine green
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85173762821&partnerID=8YFLogxK
U2 - 10.1002/macp.202300327
DO - 10.1002/macp.202300327
M3 - Article
SN - 1022-1352
VL - 224
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
IS - 24
M1 - 2300327
ER -