Individualising fortification of human milk feeds to achieve growth targets for preterm infants in the neonatal clinical care unit

Research output: ThesisDoctoral Thesis

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[Truncated abstract] This thesis provides a detailed exposition of preterm nutrition and infant body composition (BC) methods and reports four research studies as papers. The research comprised (i) a nutrition audit (Paper 1, p 107), conducted in 2006, in which calculated macronutrient intakes based on milk analysis were compared to those based on assumed composition; (ii) a BC feasibility study (Paper 2, p 140) conducted in 2007, in which the efficacy of applying a commercial two compartment (2-C) BC system to the serial measurement of preterm body composition was explored; (iii) a targeted fortification study (Paper 3, p 169), conducted in 2009, in which the fortification of human milk feeds was targeted to protein and energy recommendations on the basis of measured versus assumed composition and macronutrient influences on growth and BC were assessed using air displacement plethysmography; and (iv) an ultrasound feasibility study (Paper 4, p 197), conducted in conjunction with the intervention study, to explore the usefulness of ultrasound in assessing serial changes in preterm subcutaneous adipose and muscle tissue accretion, in response to macronutrient influences. Together, these papers add further knowledge about nutritional intakes and targeted milk fortification and as well, explore the novel application of air displacement plethysmography and ultrasound to the longitudinal assessment of preterm BC. The first research study (Paper 1, p 107) comprised a four week nutritional audit, which quantified the macronutrient intakes of 63 preterm infants from one to four weeks of life. Milk analysis was used to measure the macronutrient content of the milk feeds for a subset of infants (n=36) and to compare assumed versus measured intakes.
Original languageEnglish
QualificationDoctor of Philosophy
Publication statusUnpublished - 2010


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