Individual variation in 3-methylbutanal: A putative link between human leukocyte antigen and skin microflora

S.U. Savelev, S. Antony-Babu, S.C. Roberts, H. Wang, A.S. Clare, L.M. Gosling, M. Petrie, M. Goodfellow, A.G. O'Donnell, A.C. Ward

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The human derma emits volatile compounds whose interaction with a receiver’s olfactory sensory system may affect individual recognition and mating preferences. Studies suggest that both genes and environmental factors determine characteristic odor of an individual. We used solid-phase microextraction and gas chromatography–mass spectrometry to identify 3-methylbutanal in human axillary odor; we showed that the abundance of this volatile compound varies significantly among individuals and demonstrated that its formation in vitro may be influenced by interaction between human leukocyte antigen peptide and dermal microflora.
    Original languageEnglish
    Pages (from-to)1253-1257
    JournalJournal of Chemical Ecology
    Volume34
    Issue number9
    DOIs
    Publication statusPublished - 2008

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