Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide

Carlo A. Mallio, Gianguido Lo Vullo, Laura Messina, Bruno Beomonte Zobel, Paul M. Parizel, Carlo C. Quattrocchi

Research output: Contribution to journalArticle

Abstract

Objective The aim of this study was to assess the signal intensity of the anterior pituitary (AP) gland on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function. Materials and Methods We included 53 patients who had undergone at least 5 injections of gadodiamide and a control group of 15 subjects who underwent at least 5 brain magnetic resonance imaging without gadolinium-based contrast agents. Using unenhanced sagittal T1-weighted images, values of mean signal intensity of the AP and of the central pons were obtained. Anterior pituitary-to-pons signal intensity ratios were calculated dividing the values of the AP by those of the pons. Then, the ratios were compared between the first and the last magnetic resonance imaging scans for all the subjects. To assess the difference between the first and the last ratios, nonparametric Wilcoxon signed-rank test with Monte Carlo resampling was applied. A P value less than 0.05 was considered as statistically significant. Results The comparison between the first and the last scan revealed a statistically significant increase of AP-to-pons ratio in the last scan for the gadolinium-exposed group (P <0.001), whereas nonsignificant results were found for the control group (P = nonsignificant). Conclusions We found an increased signal intensity of the AP on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function, suggesting gadolinium deposition or long-term retention within the AP gland. Our findings need to be confirmed by further histochemical analysis of AP gland tissue samples.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalInvestigative Radiology
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 2020
Externally publishedYes

Cite this

Mallio, Carlo A. ; Lo Vullo, Gianguido ; Messina, Laura ; Zobel, Bruno Beomonte ; Parizel, Paul M. ; Quattrocchi, Carlo C. / Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide. In: Investigative Radiology. 2020 ; Vol. 55, No. 1. pp. 25-29.
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title = "Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide",
abstract = "Objective The aim of this study was to assess the signal intensity of the anterior pituitary (AP) gland on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function. Materials and Methods We included 53 patients who had undergone at least 5 injections of gadodiamide and a control group of 15 subjects who underwent at least 5 brain magnetic resonance imaging without gadolinium-based contrast agents. Using unenhanced sagittal T1-weighted images, values of mean signal intensity of the AP and of the central pons were obtained. Anterior pituitary-to-pons signal intensity ratios were calculated dividing the values of the AP by those of the pons. Then, the ratios were compared between the first and the last magnetic resonance imaging scans for all the subjects. To assess the difference between the first and the last ratios, nonparametric Wilcoxon signed-rank test with Monte Carlo resampling was applied. A P value less than 0.05 was considered as statistically significant. Results The comparison between the first and the last scan revealed a statistically significant increase of AP-to-pons ratio in the last scan for the gadolinium-exposed group (P <0.001), whereas nonsignificant results were found for the control group (P = nonsignificant). Conclusions We found an increased signal intensity of the AP on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function, suggesting gadolinium deposition or long-term retention within the AP gland. Our findings need to be confirmed by further histochemical analysis of AP gland tissue samples.",
keywords = "gadodiamide, gadolinium, pituitary gland, MRI, DENTATE NUCLEUS, CONTRAST AGENTS, GADOLINIUM DEPOSITION, IRON OVERLOAD, HUMAN BRAIN, GLOBUS-PALLIDUS, RETENTION, HEMOSIDERIN, FERROPORTIN",
author = "Mallio, {Carlo A.} and {Lo Vullo}, Gianguido and Laura Messina and Zobel, {Bruno Beomonte} and Parizel, {Paul M.} and Quattrocchi, {Carlo C.}",
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language = "English",
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journal = "Investigative Radiology",
issn = "0020-9996",
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Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide. / Mallio, Carlo A.; Lo Vullo, Gianguido; Messina, Laura; Zobel, Bruno Beomonte; Parizel, Paul M.; Quattrocchi, Carlo C.

In: Investigative Radiology, Vol. 55, No. 1, 01.2020, p. 25-29.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide

AU - Mallio, Carlo A.

AU - Lo Vullo, Gianguido

AU - Messina, Laura

AU - Zobel, Bruno Beomonte

AU - Parizel, Paul M.

AU - Quattrocchi, Carlo C.

PY - 2020/1

Y1 - 2020/1

N2 - Objective The aim of this study was to assess the signal intensity of the anterior pituitary (AP) gland on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function. Materials and Methods We included 53 patients who had undergone at least 5 injections of gadodiamide and a control group of 15 subjects who underwent at least 5 brain magnetic resonance imaging without gadolinium-based contrast agents. Using unenhanced sagittal T1-weighted images, values of mean signal intensity of the AP and of the central pons were obtained. Anterior pituitary-to-pons signal intensity ratios were calculated dividing the values of the AP by those of the pons. Then, the ratios were compared between the first and the last magnetic resonance imaging scans for all the subjects. To assess the difference between the first and the last ratios, nonparametric Wilcoxon signed-rank test with Monte Carlo resampling was applied. A P value less than 0.05 was considered as statistically significant. Results The comparison between the first and the last scan revealed a statistically significant increase of AP-to-pons ratio in the last scan for the gadolinium-exposed group (P <0.001), whereas nonsignificant results were found for the control group (P = nonsignificant). Conclusions We found an increased signal intensity of the AP on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function, suggesting gadolinium deposition or long-term retention within the AP gland. Our findings need to be confirmed by further histochemical analysis of AP gland tissue samples.

AB - Objective The aim of this study was to assess the signal intensity of the anterior pituitary (AP) gland on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function. Materials and Methods We included 53 patients who had undergone at least 5 injections of gadodiamide and a control group of 15 subjects who underwent at least 5 brain magnetic resonance imaging without gadolinium-based contrast agents. Using unenhanced sagittal T1-weighted images, values of mean signal intensity of the AP and of the central pons were obtained. Anterior pituitary-to-pons signal intensity ratios were calculated dividing the values of the AP by those of the pons. Then, the ratios were compared between the first and the last magnetic resonance imaging scans for all the subjects. To assess the difference between the first and the last ratios, nonparametric Wilcoxon signed-rank test with Monte Carlo resampling was applied. A P value less than 0.05 was considered as statistically significant. Results The comparison between the first and the last scan revealed a statistically significant increase of AP-to-pons ratio in the last scan for the gadolinium-exposed group (P <0.001), whereas nonsignificant results were found for the control group (P = nonsignificant). Conclusions We found an increased signal intensity of the AP on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function, suggesting gadolinium deposition or long-term retention within the AP gland. Our findings need to be confirmed by further histochemical analysis of AP gland tissue samples.

KW - gadodiamide

KW - gadolinium

KW - pituitary gland

KW - MRI

KW - DENTATE NUCLEUS

KW - CONTRAST AGENTS

KW - GADOLINIUM DEPOSITION

KW - IRON OVERLOAD

KW - HUMAN BRAIN

KW - GLOBUS-PALLIDUS

KW - RETENTION

KW - HEMOSIDERIN

KW - FERROPORTIN

U2 - 10.1097/RLI.0000000000000604

DO - 10.1097/RLI.0000000000000604

M3 - Article

VL - 55

SP - 25

EP - 29

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 1

ER -