Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

H. Saraswati; S. Lee; Dino Tan; E. Yunihastuti; R. Gani; P. Price

doi:10.1016/j.humimm.2015.10.002

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

H. Saraswati, S. Lee, Dino Tan, E. Yunihastuti, R. Gani, P. Price

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

© 2015 American Society for Histocompatibility and Immunogenetics.Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Human Immunology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2015.10.002
Publication status	Published - 1 Jan 2016

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title = "Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART",

abstract = "{\textcopyright} 2015 American Society for Histocompatibility and Immunogenetics.Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.",

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T1 - Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

AU - Saraswati, H.

AU - Lee, S.

AU - Tan, Dino

AU - Yunihastuti, E.

AU - Gani, R.

AU - Price, P.

PY - 2016/1/1

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N2 - © 2015 American Society for Histocompatibility and Immunogenetics.Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

AB - © 2015 American Society for Histocompatibility and Immunogenetics.Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

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DO - 10.1016/j.humimm.2015.10.002

M3 - Article

C2 - 26455474

VL - 77

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JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 1

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Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART

Abstract

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