Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica

Honghao Wang; Kai Wang; Conghui Wang; Xiaonan Zhong; Wei Qiu; Xueqiang Hu

doi:10.1177/1352458512457845

Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica

Honghao Wang, Kai Wang, Conghui Wang, Xiaonan Zhong, Wei Qiu, Xueqiang Hu

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are immune-mediated inflammatory diseases of the central nervous system. In the acute phase of these diseases, secondary ischemia due to inflammation-induced endothelial dysfunction may be an important pathological change. Pentraxin 3 (PTX3) is a pro-inflammatory protein and a novel biomarker of inflammatory vascular diseases. Objective: We aimed to determine whether PTX3 levels are elevated in MS and NMO patients. Methods: The concentrations of plasma PTX3 were measured using an enzyme-linked immunosorbent assay in 22 MS patients, 26 NMO patients, 15 acute cerebral infarction (CI) patients, 11 mild headache patients, and 14 volunteer controls. Results: During relapse, plasma PTX3 levels were higher in MS patients than in headache patients (p=0.003) and controls (p

Original language	English
Pages (from-to)	926-931
Number of pages	6
Journal	Multiple Sclerosis Journal
Volume	19
Issue number	7
DOIs	https://doi.org/10.1177/1352458512457845
Publication status	Published - Jun 2013
Externally published	Yes

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title = "Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica",

abstract = "Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are immune-mediated inflammatory diseases of the central nervous system. In the acute phase of these diseases, secondary ischemia due to inflammation-induced endothelial dysfunction may be an important pathological change. Pentraxin 3 (PTX3) is a pro-inflammatory protein and a novel biomarker of inflammatory vascular diseases. Objective: We aimed to determine whether PTX3 levels are elevated in MS and NMO patients. Methods: The concentrations of plasma PTX3 were measured using an enzyme-linked immunosorbent assay in 22 MS patients, 26 NMO patients, 15 acute cerebral infarction (CI) patients, 11 mild headache patients, and 14 volunteer controls. Results: During relapse, plasma PTX3 levels were higher in MS patients than in headache patients (p=0.003) and controls (p",

keywords = "EDSS, inflammation, multiple sclerosis, neuromyelitis optica, Pentraxin 3, relapse",

author = "Honghao Wang and Kai Wang and Conghui Wang and Xiaonan Zhong and Wei Qiu and Xueqiang Hu",

year = "2013",

month = jun,

doi = "10.1177/1352458512457845",

language = "English",

volume = "19",

pages = "926--931",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

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T1 - Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica

AU - Wang, Honghao

AU - Wang, Kai

AU - Wang, Conghui

AU - Zhong, Xiaonan

AU - Qiu, Wei

AU - Hu, Xueqiang

PY - 2013/6

Y1 - 2013/6

N2 - Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are immune-mediated inflammatory diseases of the central nervous system. In the acute phase of these diseases, secondary ischemia due to inflammation-induced endothelial dysfunction may be an important pathological change. Pentraxin 3 (PTX3) is a pro-inflammatory protein and a novel biomarker of inflammatory vascular diseases. Objective: We aimed to determine whether PTX3 levels are elevated in MS and NMO patients. Methods: The concentrations of plasma PTX3 were measured using an enzyme-linked immunosorbent assay in 22 MS patients, 26 NMO patients, 15 acute cerebral infarction (CI) patients, 11 mild headache patients, and 14 volunteer controls. Results: During relapse, plasma PTX3 levels were higher in MS patients than in headache patients (p=0.003) and controls (p

AB - Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are immune-mediated inflammatory diseases of the central nervous system. In the acute phase of these diseases, secondary ischemia due to inflammation-induced endothelial dysfunction may be an important pathological change. Pentraxin 3 (PTX3) is a pro-inflammatory protein and a novel biomarker of inflammatory vascular diseases. Objective: We aimed to determine whether PTX3 levels are elevated in MS and NMO patients. Methods: The concentrations of plasma PTX3 were measured using an enzyme-linked immunosorbent assay in 22 MS patients, 26 NMO patients, 15 acute cerebral infarction (CI) patients, 11 mild headache patients, and 14 volunteer controls. Results: During relapse, plasma PTX3 levels were higher in MS patients than in headache patients (p=0.003) and controls (p

KW - EDSS

KW - inflammation

KW - multiple sclerosis

KW - neuromyelitis optica

KW - Pentraxin 3

KW - relapse

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DO - 10.1177/1352458512457845

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JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

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Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica

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