TY - JOUR
T1 - Incidence of and risk factors for hospitalisations due to vascular complications
T2 - A population-based type 1 diabetes cohort (n=1316) followed into early adulthood
AU - Cooper, Matthew N.
AU - de Bock, Martin I.
AU - Carter, Kim W.
AU - de Klerk, Nicholas H.
AU - Jones, Timothy
AU - Davis, Elizabeth A.
PY - 2017/5
Y1 - 2017/5
N2 - Aim: To determine the incidence of hospitalisations and risk factors for vascular complications experienced during early adulthood in patients with childhood onset type 1 diabetes. Methods: A population-based childhood onset type 1 diabetes cohort was identified from a statewide register (1992-2012). Data linkage was used to identify a matched comparison cohort. Hospital admissions data were extracted to follow up both cohorts into early adulthood (1975-2012). Results: The type 1 diabetes cohort (n = 1316) had a mean age of diagnosis of 9.5. years, 49.5% were women and mean age at the end of follow-up was 26.3. years (range 18-38). Within the type 1 diabetes cohort 32 (2.4%) were hospitalised with a vascular complication during early adulthood. Poor glycaemic control during paediatric management was associated with a significant increase in risk for ophthalmic complication with 19.4% (n = 12/62) of those with a mean HbA1c >. 12% (108. mmol/mol) diagnosed compared to 0.72% (n = 5/696) of those with mean HbA1c <. 9% (75. mmol/mol), adjusted hazard ratio 8.4 (95% CI 2.0, 34.7). Conclusion: Severe vascular complications requiring hospital admission continue to be observed during early adulthood. Both women and those with poor glycaemic control are at increased risk of requiring a hospital admission for these complications during early adulthood.
AB - Aim: To determine the incidence of hospitalisations and risk factors for vascular complications experienced during early adulthood in patients with childhood onset type 1 diabetes. Methods: A population-based childhood onset type 1 diabetes cohort was identified from a statewide register (1992-2012). Data linkage was used to identify a matched comparison cohort. Hospital admissions data were extracted to follow up both cohorts into early adulthood (1975-2012). Results: The type 1 diabetes cohort (n = 1316) had a mean age of diagnosis of 9.5. years, 49.5% were women and mean age at the end of follow-up was 26.3. years (range 18-38). Within the type 1 diabetes cohort 32 (2.4%) were hospitalised with a vascular complication during early adulthood. Poor glycaemic control during paediatric management was associated with a significant increase in risk for ophthalmic complication with 19.4% (n = 12/62) of those with a mean HbA1c >. 12% (108. mmol/mol) diagnosed compared to 0.72% (n = 5/696) of those with mean HbA1c <. 9% (75. mmol/mol), adjusted hazard ratio 8.4 (95% CI 2.0, 34.7). Conclusion: Severe vascular complications requiring hospital admission continue to be observed during early adulthood. Both women and those with poor glycaemic control are at increased risk of requiring a hospital admission for these complications during early adulthood.
KW - Glycemic control
KW - Hospitalization
KW - Macrovascular complications
KW - Microvascular complications
KW - Type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85013673481&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2016.11.022
DO - 10.1016/j.jdiacomp.2016.11.022
M3 - Article
C2 - 28242271
AN - SCOPUS:85013673481
VL - 31
SP - 843
EP - 849
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
SN - 1056-8727
IS - 5
ER -