Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow up study of 5 years.

Dina Lo Giudice; Kate Smith; S Fenner; Zoe Hyde; David Atkinson; Linda Skeaf; Ros Malay; Leon Flicker

doi:10.1016/j.jalz.2015.01.009

Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow up study of 5 years.

Dina Lo Giudice, Kate Smith, S Fenner, Zoe Hyde, David Atkinson, Linda Skeaf, Ros Malay, Leon Flicker

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Introduction
Aboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown.

Methods
This was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia.

Results
At follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP.

Discussion
Dementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.

Original language	English
Pages (from-to)	252-261
Number of pages	10
Journal	Alzheimer's & Dementia
Volume	12
Issue number	3
Early online date	18 May 2015
DOIs	https://doi.org/10.1016/j.jalz.2015.01.009
Publication status	Published - 1 Mar 2016

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10.1016/j.jalz.2015.01.009

Health Outcomes of Older Indigenous Australians - a 5 Year Follow up Study of a Population at Risk
LoGiudice, D., Flicker, L., Smith, K. & Atkinson, D.
National Health & Medical Research Council NHMRC
1/01/10 → 31/12/12
Project: Research

Cite this

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title = "Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow up study of 5 years.",

abstract = "IntroductionAboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown.MethodsThis was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia.ResultsAt follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP.DiscussionDementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.",

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T1 - Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow up study of 5 years.

AU - Lo Giudice, Dina

AU - Smith, Kate

AU - Fenner, S

AU - Hyde, Zoe

AU - Atkinson, David

AU - Skeaf, Linda

AU - Malay, Ros

AU - Flicker, Leon

PY - 2016/3/1

Y1 - 2016/3/1

N2 - IntroductionAboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown.MethodsThis was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia.ResultsAt follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP.DiscussionDementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.

AB - IntroductionAboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown.MethodsThis was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia.ResultsAt follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP.DiscussionDementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.

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DO - 10.1016/j.jalz.2015.01.009

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SP - 252

EP - 261

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 3

ER -

Incidence and predictors of cognitive impairment and dementia in Aboriginal Australians: A follow up study of 5 years.

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Health Outcomes of Older Indigenous Australians - a 5 Year Follow up Study of a Population at Risk

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