Inactivation of Endoplasmic Reticulum stress and the prevention of Neurodegenerative diseases

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Abstract

Biotherapeutics and nutritional therapy are essential for the
treatment of endoplasmic reticulum (ER) stress in diabetes and
neurodegenerative diseases. Oxidative stress and nutrient excess
may induce ER stress associated with activation of the unfolded
protein response and connected to cell death. The heat shock
gene Sirtuin 1 (Sirt 1) is important to the heat shock response
with amyloid beta aggregation associated with the induction of
mitophagy and ER stress in neuron cells. Genomic medicine that
activates nuclear Sirt 1 is essential for the prevention of
mitochondrial apoptosis and ER stress. Inhibitors such as drugs,
alcohol, excess caffeine and palmitic acid may override the
therapeutic effects of Sirt 1 activators with relevance to ER stress
associated cell life and death decisions.
Original languageEnglish
Pages22-25
Number of pages4
Volume2
No.2
Specialist publicationResearch and Reviews: Neuroscience
Publication statusPublished - 20 Dec 2018

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