In vivo volumetric quantitative micro-elastography of human skin

Shaghayegh Es’haghian, Kelsey Kennedy, Peijun Gong, Qingyun Li, Lixin Chin, Philip Wijesinghe, David D. Sampson, Robert McLaughlin, Brendan F. Kennedy

Research output: Contribution to journalArticle

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In this paper, we demonstrate in vivo volumetric quantitative micro-elastography of human skin. Elasticity is estimated at each point in the captured volume by combining local axial strain measured in the skin with local axial stress estimated at the skin surface. This is achieved by utilizing phase-sensitive detection to measure axial displacements resulting from compressive loading of the skin and an overlying, compliant, transparent layer with known stress/strain behavior. We use an imaging probe head that provides optical coherence tomography imaging and compression from the same direction. We demonstrate our technique on a tissue phantom containing a rigid inclusion, and present in vivo elastograms acquired from locations on the hand, wrist, forearm and leg of human volunteers.
Original languageEnglish
Pages (from-to)2458-2471
JournalBiomedical Optics Express
Issue number5
Publication statusPublished - 1 May 2017

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