In vivo optical elastography: Stress and strain imaging of human skin lesions

Shaghayegh Es'Haghian, Peijun Gong, Kelsey Kennedy, Philip Wijesinghe, David Sampson, Robert Mclaughlin, Brendan Kennedy

Research output: Chapter in Book/Conference paperConference paper

3 Citations (Scopus)

Abstract

© 2015 SPIE. Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.
Original languageEnglish
Title of host publicationProceedings of SPIE: Optical Elastography and Tissue Biomechanics II
Place of PublicationWashington, USA
PublisherSPIE
Pages93270C-1 - 93270C-8
Volume9327
ISBN (Print)9781628414172
DOIs
Publication statusPublished - 2015
EventSPIE BiOS 2015 - San Francsisco, United States
Duration: 7 Feb 201512 Feb 2015

Conference

ConferenceSPIE BiOS 2015
CountryUnited States
CitySan Francsisco
Period7/02/1512/02/15

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pathology
imaging techniques
lesions
mechanical properties
scars
probes
high resolution
silicones
tomography

Cite this

Es'Haghian, S., Gong, P., Kennedy, K., Wijesinghe, P., Sampson, D., Mclaughlin, R., & Kennedy, B. (2015). In vivo optical elastography: Stress and strain imaging of human skin lesions. In Proceedings of SPIE: Optical Elastography and Tissue Biomechanics II (Vol. 9327, pp. 93270C-1 - 93270C-8). Washington, USA: SPIE. https://doi.org/10.1117/12.2078706
Es'Haghian, Shaghayegh ; Gong, Peijun ; Kennedy, Kelsey ; Wijesinghe, Philip ; Sampson, David ; Mclaughlin, Robert ; Kennedy, Brendan. / In vivo optical elastography: Stress and strain imaging of human skin lesions. Proceedings of SPIE: Optical Elastography and Tissue Biomechanics II. Vol. 9327 Washington, USA : SPIE, 2015. pp. 93270C-1 - 93270C-8
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abstract = "{\circledC} 2015 SPIE. Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.",
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Es'Haghian, S, Gong, P, Kennedy, K, Wijesinghe, P, Sampson, D, Mclaughlin, R & Kennedy, B 2015, In vivo optical elastography: Stress and strain imaging of human skin lesions. in Proceedings of SPIE: Optical Elastography and Tissue Biomechanics II. vol. 9327, SPIE, Washington, USA, pp. 93270C-1 - 93270C-8, SPIE BiOS 2015, San Francsisco, United States, 7/02/15. https://doi.org/10.1117/12.2078706

In vivo optical elastography: Stress and strain imaging of human skin lesions. / Es'Haghian, Shaghayegh; Gong, Peijun; Kennedy, Kelsey; Wijesinghe, Philip; Sampson, David; Mclaughlin, Robert; Kennedy, Brendan.

Proceedings of SPIE: Optical Elastography and Tissue Biomechanics II. Vol. 9327 Washington, USA : SPIE, 2015. p. 93270C-1 - 93270C-8.

Research output: Chapter in Book/Conference paperConference paper

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AB - © 2015 SPIE. Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.

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Es'Haghian S, Gong P, Kennedy K, Wijesinghe P, Sampson D, Mclaughlin R et al. In vivo optical elastography: Stress and strain imaging of human skin lesions. In Proceedings of SPIE: Optical Elastography and Tissue Biomechanics II. Vol. 9327. Washington, USA: SPIE. 2015. p. 93270C-1 - 93270C-8 https://doi.org/10.1117/12.2078706