Abstract
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique which is FDA approved
for treatment of medication-resistant depression. However, the mechanisms underlying its therapeutic effects remain poorly understood. This thesis characterises the effects of low-intensity rTMS on brain function, chemistry, and structure using MRI in healthy rats and in a rat model of depression. The use of MRI in animal models allows for a direct comparison of animal and human data and hence, will facilitate the development of optimal stimulation protocols and their translation to the clinic, which will improve the efficacy of rTMS as a therapeutic tool.
for treatment of medication-resistant depression. However, the mechanisms underlying its therapeutic effects remain poorly understood. This thesis characterises the effects of low-intensity rTMS on brain function, chemistry, and structure using MRI in healthy rats and in a rat model of depression. The use of MRI in animal models allows for a direct comparison of animal and human data and hence, will facilitate the development of optimal stimulation protocols and their translation to the clinic, which will improve the efficacy of rTMS as a therapeutic tool.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 10 Jan 2022 |
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| Publication status | Unpublished - 2022 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - SEEWOO, Bhedita Jaya - 2022 - Part2
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