In-vivo MRI study of the effects of low-intensity rTMS on brain activity, chemistry and structure in rats.

Research output: ThesisDoctoral Thesis

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique which is FDA approved
for treatment of medication-resistant depression. However, the mechanisms underlying its therapeutic effects remain poorly understood. This thesis characterises the effects of low-intensity rTMS on brain function, chemistry, and structure using MRI in healthy rats and in a rat model of depression. The use of MRI in animal models allows for a direct comparison of animal and human data and hence, will facilitate the development of optimal stimulation protocols and their translation to the clinic, which will improve the efficacy of rTMS as a therapeutic tool.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Rodger, Jennifer, Supervisor
  • Feindel, Kirk, Supervisor
  • Etherington, Sarah J., Supervisor, External person
Thesis sponsors
Award date10 Jan 2022
DOIs
Publication statusUnpublished - 2022

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