In vivo imaging of the depth-resolved optic axis of birefringence in human skin

Qingyun Li, David D. Sampson, Martin Villiger

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recent progress has enabled the reconstruction of the local (i.e., depth-resolved) optic axis (OAx) of biological tissue from measurements made with polarization-sensitive optical coherence tomography (PS-OCT). Here we demonstrate local OAx imaging in healthy human skin in vivo. The images reveal dense, weaving patterns that are imperceptible in OCT intensity tomograms or conventional PS-OCT metrics and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen. Using co-registered polarization-sensitive optical coherence microscopy, we furthermore investigated the impact of spatial resolution on the recovered OAx patterns and confirmed their consistency. OAx orientation as a contrast mechanism merits further exploration for applications in dermatology.

Original languageEnglish
Pages (from-to)4919-4922
Number of pages4
JournalOptics Letters
Volume45
Issue number17
DOIs
Publication statusPublished - 1 Sep 2020

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