In vivo dynamic optical coherence elastography using a ring actuator

Brendan Kennedy, Timothy Hillman, Robert Mclaughlin, Bryden Quirk, David Sampson

    Research output: Contribution to journalArticlepeer-review

    124 Citations (Scopus)

    Abstract

    We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were coupled to samples that were imaged using optical coherence tomography. The resulting vibration amplitude and microstrain maps are presented for bilayer silicone phantoms and multiple skin sites on a human subject. Contrast based on the differing elastic properties is shown, notably between the epidermis and dermis. The results constitute the first demonstration of a practical means of performing in vivo dynamic optical coherence elastography on a human subject.© 2009 OSA
    Original languageEnglish
    Pages (from-to)21762-21772
    JournalOptics Express
    Volume17
    Issue number24
    DOIs
    Publication statusPublished - 2009

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