In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

K.C. Carson; J.G. Bartlett; T-J. Tan; Thomas Riley

doi:10.1128/AAC.00771-07

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

K.C. Carson, J.G. Bartlett, T-J. Tan, Thomas Riley

Graduate Research School

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (2:1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

Original language	English
Pages (from-to)	4505-4507
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00771-07
Publication status	Published - 2007

Access to Document

10.1128/AAC.00771-07

Cite this

@article{381b4e5866454e2abd8e46c69e61ada9,

title = "In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate",

abstract = "The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (2:1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.",

author = "K.C. Carson and J.G. Bartlett and T-J. Tan and Thomas Riley",

year = "2007",

doi = "10.1128/AAC.00771-07",

language = "English",

volume = "51",

pages = "4505--4507",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "12",

}

TY - JOUR

T1 - In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

AU - Carson, K.C.

AU - Bartlett, J.G.

AU - Tan, T-J.

AU - Riley, Thomas

PY - 2007

Y1 - 2007

N2 - The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (2:1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

AB - The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (2:1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

U2 - 10.1128/AAC.00771-07

DO - 10.1128/AAC.00771-07

M3 - Article

C2 - 17908948

VL - 51

SP - 4505

EP - 4507

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 12

ER -

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

Abstract

Access to Document

Fingerprint

Cite this