In vitro loading models for tendon mechanobiology

Tao Wang, Peilin Chen, Monica Zheng, Allan Wang, David Lloyd, Toby Leys, Qiujian Zheng, Ming H Zheng

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Tendons are the connective tissue responsible for transferring force from muscles to bones. A key factor in tendon development, maturation, repair, and degradation is its biomechanical environment. Understanding tendon mechanobiology is essential for the development of injury prevention strategies, rehabilitation protocols and potentially novel treatments in tendon injury and degeneration. Despite the simple overall loading on tendon tissue, cells within the tissue in vivo experience a much more complex mechanical environment including tension, compression and shear forces. This creates a substantial challenge in the establishment of in vitro loading models of the tendon. This article reviews multiple loading models used for the study of tendon mechanobiology and summarizes the main findings. Although impressive progress has been achieved in the functionality and mimicry of in vitro loading models, an ideal platform is yet to be developed. Multidisciplinary approaches and collaborations will be the key to unveiling the tendon mechanobiology. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:566-575, 2018.

Original languageEnglish
Pages (from-to)566-575
Number of pages10
JournalJournal of Orthopaedic Research: a journal for musculoskeletal investigations
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2018
Externally publishedYes

Fingerprint

Biophysics
Tendons
Tendon Injuries
In Vitro Techniques
Connective Tissue
Rehabilitation
Bone and Bones
Muscles
Wounds and Injuries

Cite this

Wang, Tao ; Chen, Peilin ; Zheng, Monica ; Wang, Allan ; Lloyd, David ; Leys, Toby ; Zheng, Qiujian ; Zheng, Ming H. / In vitro loading models for tendon mechanobiology. In: Journal of Orthopaedic Research: a journal for musculoskeletal investigations. 2018 ; Vol. 36, No. 2. pp. 566-575.
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abstract = "Tendons are the connective tissue responsible for transferring force from muscles to bones. A key factor in tendon development, maturation, repair, and degradation is its biomechanical environment. Understanding tendon mechanobiology is essential for the development of injury prevention strategies, rehabilitation protocols and potentially novel treatments in tendon injury and degeneration. Despite the simple overall loading on tendon tissue, cells within the tissue in vivo experience a much more complex mechanical environment including tension, compression and shear forces. This creates a substantial challenge in the establishment of in vitro loading models of the tendon. This article reviews multiple loading models used for the study of tendon mechanobiology and summarizes the main findings. Although impressive progress has been achieved in the functionality and mimicry of in vitro loading models, an ideal platform is yet to be developed. Multidisciplinary approaches and collaborations will be the key to unveiling the tendon mechanobiology. {\circledC} 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:566-575, 2018.",
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In vitro loading models for tendon mechanobiology. / Wang, Tao; Chen, Peilin; Zheng, Monica; Wang, Allan; Lloyd, David; Leys, Toby; Zheng, Qiujian; Zheng, Ming H.

In: Journal of Orthopaedic Research: a journal for musculoskeletal investigations, Vol. 36, No. 2, 02.2018, p. 566-575.

Research output: Contribution to journalReview article

TY - JOUR

T1 - In vitro loading models for tendon mechanobiology

AU - Wang, Tao

AU - Chen, Peilin

AU - Zheng, Monica

AU - Wang, Allan

AU - Lloyd, David

AU - Leys, Toby

AU - Zheng, Qiujian

AU - Zheng, Ming H

N1 - © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

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AB - Tendons are the connective tissue responsible for transferring force from muscles to bones. A key factor in tendon development, maturation, repair, and degradation is its biomechanical environment. Understanding tendon mechanobiology is essential for the development of injury prevention strategies, rehabilitation protocols and potentially novel treatments in tendon injury and degeneration. Despite the simple overall loading on tendon tissue, cells within the tissue in vivo experience a much more complex mechanical environment including tension, compression and shear forces. This creates a substantial challenge in the establishment of in vitro loading models of the tendon. This article reviews multiple loading models used for the study of tendon mechanobiology and summarizes the main findings. Although impressive progress has been achieved in the functionality and mimicry of in vitro loading models, an ideal platform is yet to be developed. Multidisciplinary approaches and collaborations will be the key to unveiling the tendon mechanobiology. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:566-575, 2018.

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