In Vitro Interactions beteween Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Timothy Davis; Juliana Hamzah; Kenneth Ilett; H.A. Karunajeewa; J.C. Reeder; K.T. Batty; S. Hackett; Hugh Barrett

doi:10.1128/AAC.00177-06

In Vitro Interactions beteween Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Timothy Davis, Juliana Hamzah, Kenneth Ilett, H.A. Karunajeewa, J.C. Reeder, K.T. Batty, S. Hackett, Hugh Barrett

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.

Original language	English
Pages (from-to)	2883-2885
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00177-06
Publication status	Published - 2006

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abstract = "In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.",

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AU - Davis, Timothy

AU - Hamzah, Juliana

AU - Ilett, Kenneth

AU - Karunajeewa, H.A.

AU - Reeder, J.C.

AU - Batty, K.T.

AU - Hackett, S.

AU - Barrett, Hugh

PY - 2006

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AB - In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.

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DO - 10.1128/AAC.00177-06

M3 - Article

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SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

In Vitro Interactions beteween Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Abstract

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