In Vitro Interactions beteween Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Timothy Davis, Juliana Hamzah, Kenneth Ilett, H.A. Karunajeewa, J.C. Reeder, K.T. Batty, S. Hackett, Hugh Barrett

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.
Original languageEnglish
Pages (from-to)2883-2885
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number8
DOIs
Publication statusPublished - 2006

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