In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor

Research output: Chapter in Book/Conference paperChapterpeer-review

4 Citations (Scopus)


Bioreactors can offer an advanced platform to provide conditions that mimic the native microenvironment, which can also provide stretching environment for mechanobiology research. Tendon-derived stem cells (TDSCs) are a type of mechanosensitive and multipotent cells, which behave differently in diverse mechanical stretching environments. We have proved the in vitro three-dimensional (3D) mechanical stimulation could closely mimic the stretching environment in vivo. Thus, here we describe applying a customized bioreactor to provide 3D force for mechanical stimulation on TDSC in vitro.

Original languageEnglish
Title of host publicationBioreactors in Stem Cell Biology
Subtitle of host publicationMethods and Protocols
EditorsKursad Turksen
Place of PublicationUSA
PublisherHumana Press Inc.
Number of pages10
ISBN (Electronic)978-1-0716-2018-2
ISBN (Print)978-1-0716-2017-5
Publication statusPublished - 2022

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


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