Abstract
Cardiovascular disease (CVD) remains a leading cause of death. Preventative therapies that reduce CVD are most effective when targeted to individuals at high risk. Current risk stratification tools have only modest prognostic capabilities, resulting in over-treatment of low-risk individuals and under-treatment of high-risk individuals. Improved methods of CVD risk stratification are required. Molecular imaging offers a novel approach to CVD risk stratification. In particular, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque features and vascular calcification activity, which predicts future development of new vascular calcium deposits. The rate of change of coronary calcium scores, measured by serial computed tomography scans over a 2-year period, is a strong predictor of CVD risk. Vascular calcification activity, as measured with 18F-NaF PET, has the potential to provide prognostic information similar to consecutive coronary calcium scoring, with a single-time-point convenience. However, owing to the rapid motion and small size of the coronary arteries, new solutions are required to address the traditional limitations of PET imaging. Two different methods of coronary PET analysis have been independently proposed and here we compare their respective strengths, weaknesses, and the potential for clinical translation.
| Original language | English |
|---|---|
| Pages (from-to) | 1774-1783 |
| Journal | Journal of Nuclear Cardiology |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| Publication status | E-pub ahead of print - 10 Jul 2018 |
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In search of the vulnerable patient or the vulnerable plaque : F-sodium fluoride positron emission tomography for cardiovascular risk stratification. / Bellinge, Jamie W; Francis, Roslyn J; Majeed, Kamran; Watts, Gerald F; Schultz, Carl J.
In: Journal of Nuclear Cardiology, Vol. 25, No. 5, 10.07.2018, p. 1774-1783.Research output: Contribution to journal › Review article
TY - JOUR
T1 - In search of the vulnerable patient or the vulnerable plaque
T2 - F-sodium fluoride positron emission tomography for cardiovascular risk stratification
AU - Bellinge, Jamie W
AU - Francis, Roslyn J
AU - Majeed, Kamran
AU - Watts, Gerald F
AU - Schultz, Carl J
PY - 2018/7/10
Y1 - 2018/7/10
N2 - Cardiovascular disease (CVD) remains a leading cause of death. Preventative therapies that reduce CVD are most effective when targeted to individuals at high risk. Current risk stratification tools have only modest prognostic capabilities, resulting in over-treatment of low-risk individuals and under-treatment of high-risk individuals. Improved methods of CVD risk stratification are required. Molecular imaging offers a novel approach to CVD risk stratification. In particular, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque features and vascular calcification activity, which predicts future development of new vascular calcium deposits. The rate of change of coronary calcium scores, measured by serial computed tomography scans over a 2-year period, is a strong predictor of CVD risk. Vascular calcification activity, as measured with 18F-NaF PET, has the potential to provide prognostic information similar to consecutive coronary calcium scoring, with a single-time-point convenience. However, owing to the rapid motion and small size of the coronary arteries, new solutions are required to address the traditional limitations of PET imaging. Two different methods of coronary PET analysis have been independently proposed and here we compare their respective strengths, weaknesses, and the potential for clinical translation.
AB - Cardiovascular disease (CVD) remains a leading cause of death. Preventative therapies that reduce CVD are most effective when targeted to individuals at high risk. Current risk stratification tools have only modest prognostic capabilities, resulting in over-treatment of low-risk individuals and under-treatment of high-risk individuals. Improved methods of CVD risk stratification are required. Molecular imaging offers a novel approach to CVD risk stratification. In particular, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque features and vascular calcification activity, which predicts future development of new vascular calcium deposits. The rate of change of coronary calcium scores, measured by serial computed tomography scans over a 2-year period, is a strong predictor of CVD risk. Vascular calcification activity, as measured with 18F-NaF PET, has the potential to provide prognostic information similar to consecutive coronary calcium scoring, with a single-time-point convenience. However, owing to the rapid motion and small size of the coronary arteries, new solutions are required to address the traditional limitations of PET imaging. Two different methods of coronary PET analysis have been independently proposed and here we compare their respective strengths, weaknesses, and the potential for clinical translation.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85049674943&origin=resultslist&sort=plf-f&src=s&st1=In+search+of+the+vulnerable+patient+or+the+vulnerable+plaque%3a+18F-sodium+fluoride+positron+emission+tomography+for+cardiovascular+risk+stratification&st2=&sid=65070d18a1d44c8253beb75326dd335c&sot=b&sdt=b&sl=164&s=TITLE-ABS-KEY%28In+search+of+the+vulnerable+patient+or+the+vulnerable+plaque%3a+18F-sodium+fluoride+positron+emission+tomography+for+cardiovascular+risk+stratification%29&relpos=0&citeCnt=0&searchTerm=
U2 - 10.1007/s12350-018-1360-2
DO - 10.1007/s12350-018-1360-2
M3 - Review article
VL - 25
SP - 1774
EP - 1783
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 5
ER -