TY - JOUR
T1 - In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics
AU - Longman-Jacobsen, N.
AU - Williamson, J.F.
AU - Dawkins, R.L.
AU - Gaudieri, Silvana
PY - 2003
Y1 - 2003
N2 - Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs. (C) 2003 Elsevier Science B.V. All rights reserved.
AB - Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs. (C) 2003 Elsevier Science B.V. All rights reserved.
U2 - 10.1016/S0378-1119(03)00621-8
DO - 10.1016/S0378-1119(03)00621-8
M3 - Article
VL - 312
SP - 257
EP - 261
JO - Gene
JF - Gene
SN - 0378-1119
ER -