In-depth study of a highly efficient enantioselective intramolecular hydroamination reaction and it's applications

Daven Foster

Research output: ThesisDoctoral Thesis

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Abstract

The catalytic hydroamination reaction is an effective and atom economic way to prepare a variety of amines from simple olefins. The intramolecular hydroamination reaction involves the cyclization of amino olefin substrates to form 5-, 6- and 7-memberedN-heterocycles. During my PhD, I have developed and explored several properties of a variety of N-heterocyclic carbenes, expanded the reaction scope and mechanistically explored the iridium catalyzed asymmetric intramolecular hydroamination reaction, and applied the intramolecular hydroamination reaction for use in asymmetric total synthesis and the efficient production of new chiral catalysts and ancillary ligands.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Dorta, Reto, Supervisor
  • Koutsantonis, George, Supervisor
Thesis sponsors
Award date19 Apr 2023
DOIs
Publication statusUnpublished - 2022

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