Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

John S. Tsang, Carlota Dobaño, Pierre VanDamme, Gemma Moncunill, Arnaud Marchant, Rym Ben Othman, Manish Sadarangani, Wayne C. Koff, Tobias R. Kollmann

Research output: Contribution to journalReview articlepeer-review

34 Citations (Web of Science)


Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies (‘precision vaccination’). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalTrends in Immunology
Issue number6
Publication statusPublished - Jun 2020


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