Improving the efficacy and delivery of therapeutics for cardiovascular disease

Ashay Shah

Research output: ThesisDoctoral Thesis

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Cardiovascular disease is the leading cause of death globally. lschemic heart disease, including myocardial infarction accounts for half of cardiovascular disease related deaths. Removal of the coronary obstruction causing myocardial infarction is associated with an increase in subsequent damage to the heart, a paradox known as ischemia reperfusion injury. This thesis investigates the use of novel peptides and delivery mechanisms to improve therapeutics for cardiovascular disease. Optimised nanotechnology represents a platform to deliver peptides as a therapeutic approach for the prevention of ischemia reperfusion injury. If clinically translated, this treatment can significantly reduce cardiovascular disease associated morbidity and morality.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Hool, Livia, Supervisor
  • Swaminatha Iyer, Killugudi, Supervisor
Thesis sponsors
Award date18 Sept 2020
Publication statusUnpublished - 2020


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