Cardiovascular disease is the leading cause of death globally. lschemic heart disease, including myocardial infarction accounts for half of cardiovascular disease related deaths. Removal of the coronary obstruction causing myocardial infarction is associated with an increase in subsequent damage to the heart, a paradox known as ischemia reperfusion injury. This thesis investigates the use of novel peptides and delivery mechanisms to improve therapeutics for cardiovascular disease. Optimised nanotechnology represents a platform to deliver peptides as a therapeutic approach for the prevention of ischemia reperfusion injury. If clinically translated, this treatment can significantly reduce cardiovascular disease associated morbidity and morality.
|Qualification||Doctor of Philosophy|
|Award date||18 Sept 2020|
|Publication status||Unpublished - 2020|