Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties

Philip Wijesinghe

doi:10.4225/23/5a6926ff6f524

Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties

Philip Wijesinghe

Research output: Thesis › Doctoral Thesis

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Abstract

The mechanical properties of tissue are inextricably linked to biological form and function. They are important from the
molecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease.
Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presents
the development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherence
elastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to new
discoveries on the role of mechanics in tissue development, organization and pathogenesis.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Kennedy, Brendan, Supervisor Sampson, David Douglas, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	10 Jan 2018
DOIs	https://doi.org/10.4225/23/5a6926ff6f524
Publication status	Unpublished - 2018

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THESIS - DOCTOR OF PHILOSOPHY - WIJESINGHE Philip - 2018
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title = "Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties",

abstract = "The mechanical properties of tissue are inextricably linked to biological form and function. They are important from the molecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease. Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presents the development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherence elastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to new discoveries on the role of mechanics in tissue development, organization and pathogenesis.",

keywords = "tissue elasticity imaging, optical coherence tomography, elastography, tissue mechanics, cell mechanics, numerical methods",

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AB - The mechanical properties of tissue are inextricably linked to biological form and function. They are important from the molecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease. Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presents the development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherence elastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to new discoveries on the role of mechanics in tissue development, organization and pathogenesis.

KW - tissue elasticity imaging

KW - optical coherence tomography

KW - elastography

KW - tissue mechanics

KW - cell mechanics

KW - numerical methods

U2 - 10.4225/23/5a6926ff6f524

DO - 10.4225/23/5a6926ff6f524

M3 - Doctoral Thesis

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Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties

Abstract

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