Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties

Philip Wijesinghe

    Research output: ThesisDoctoral Thesis

    197 Downloads (Pure)

    Abstract

    The mechanical properties of tissue are inextricably linked to biological form and function. They are important from the
    molecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease.
    Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presents
    the development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherence
    elastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to new
    discoveries on the role of mechanics in tissue development, organization and pathogenesis.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Kennedy, Brendan, Supervisor
    • Sampson, David, Supervisor
    Thesis sponsors
    Award date10 Jan 2018
    DOIs
    Publication statusUnpublished - 2018

    Fingerprint

    Elasticity Imaging Techniques
    Mechanics
    Regeneration
    Research

    Cite this

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    title = "Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties",
    abstract = "The mechanical properties of tissue are inextricably linked to biological form and function. They are important from themolecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease.Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presentsthe development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherenceelastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to newdiscoveries on the role of mechanics in tissue development, organization and pathogenesis.",
    keywords = "tissue elasticity imaging, optical coherence tomography, elastography, tissue mechanics, cell mechanics, numerical methods",
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    school = "The University of Western Australia",

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    AB - The mechanical properties of tissue are inextricably linked to biological form and function. They are important from themolecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease.Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presentsthe development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherenceelastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to newdiscoveries on the role of mechanics in tissue development, organization and pathogenesis.

    KW - tissue elasticity imaging

    KW - optical coherence tomography

    KW - elastography

    KW - tissue mechanics

    KW - cell mechanics

    KW - numerical methods

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    DO - 10.4225/23/5a6926ff6f524

    M3 - Doctoral Thesis

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