Improving the accuracy, resolution and contrast of optical coherence elastography toward cellular scale imaging of mechanical properties

Philip Wijesinghe

    Research output: ThesisDoctoral Thesis

    229 Downloads (Pure)

    Abstract

    The mechanical properties of tissue are inextricably linked to biological form and function. They are important from the
    molecular to the organ scales, and are implicated in healthy development, tissue regeneration and manifestation of disease.
    Optical coherence elastography is emerging as a promising method to characterize tissue mechanics. This thesis presents
    the development of new methods and techniques to improve the accuracy, resolution and contrast of optical coherence
    elastography, and establish it as a platform for fundamental and clinical research. The platform may offer a window to new
    discoveries on the role of mechanics in tissue development, organization and pathogenesis.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Kennedy, Brendan, Supervisor
    • Sampson, David Douglas, Supervisor
    Thesis sponsors
    Award date10 Jan 2018
    DOIs
    Publication statusUnpublished - 2018

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