Improvements in the preparation of a key imidazylate and the reduction of the derived nitrile have led to more efficient syntheses of isofagomine, noeuromycin, azafagomine, and isofagomine lactam. As well, a precursor of azafagomine has been converted into azanoeuromycin, and the nitrogen atom of isofagomine has been incorporated into a guanidine residue.
|Journal||Australian Journal of Chemistry: an international journal for chemical science|
|Publication status||Published - 2006|
Meloncelli, P. J., & Stick, R. (2006). Improvements to the Synthesis of Isofagomine, Noeuromycin, Azafagomine, and Isofagomine Lactam, and a Synthesis of Azanoeuromycin and 'Guanidine' Isofagomine. Australian Journal of Chemistry: an international journal for chemical science, 59(11), 827-833. https://doi.org/10.1071/CH06241