Impaired sleep and alertness in Parkinson’s disease: “What did we learn from animal models?”

Pierre Hervé Luppi, Olivier Clément, Sara Valencia Garcia, Frédéric Brischoux, Patrice Fort

Research output: Chapter in Book/Conference paperChapterpeer-review

Abstract

The aim of this review is to try to provide a conceptual framework on the mechanisms potentially responsible for sleep alteration in Parkinson’s disease (PD) based on data obtained in animals. We first provide state-of-the-art hypotheses on the mechanisms responsible for the succession of the three vigilance states, namely waking, non-rapid eye movement (non-REM) also called slow-wave sleep (SWS) and REM sleep also called paradoxical sleep (PS). We then review our knowledge on the role of dopamine in sleep-waking regulation. We pursue by discussing the results obtained on sleep in MPTP animal model of PD. We complete our review by providing hypotheses on the mechanisms responsible for REM sleep behavior disorder known to occur in half of the Parkinson’s patients based on studies of RBD animal models.

Original languageEnglish
Title of host publicationDisorders of Sleep and Circadian Rhythms in Parkinson's Disease
PublisherSpringer-Verlag Vienna
Pages35-49
Number of pages15
ISBN (Electronic)9783709116319
ISBN (Print)9783709116302
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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