Impaired skin blood flow response to environmental heating in chronic heart failure

Daniel Green, A.J. Maiorana, J.S. Ha, Valerie Burke, M. Erickson, C.T. Minson, W. Bilsborough, G. O'Driscoll

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Aims We examined the thermoregulatory response to heat exposure in patients with chronic heart failure.Methods and results Skin blood flow (SkBF) was measured in HF subjects and matched controls. Cutaneous vascular conductance (CVC) was calculated from laser-Doppler SkBF and blood pressure. To assess the nitric oxide contribution to thermoregulatory responses, subcutaneous microdialysis membranes were placed beneath the laser-Doppler probes to infuse NG-nitro-L-arginine methyl ester (L-NAME), or Ringer's solution. Core (TC) and skin temperatures (five sites, TSk) were continuously recorded. Subjects were studied during normothermia then at 38°C, 50%RH within a climate chamber. TC and TSk did not differ between HF and controls during normothermia and heating induced similar increases in both groups. During heating, CVC rose in both groups, but significantly less so in HF (HF 43.9±7.8 vs. controls 58.0±7.5% CVCmax, P
Original languageEnglish
Pages (from-to)338-343
JournalEuropean Heart Journal
Volume27
Issue number3
DOIs
Publication statusPublished - 2006

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