Impaired memory B cell IgG isotype switching and circulating T follicular-helper cell dysfunction in patients with chronic HIV-1 infection

Naamah Laila Abudulai

Impaired memory B cell IgG isotype switching and circulating T follicular-helper cell dysfunction in patients with chronic HIV-1 infection

Naamah Laila Abudulai

Research output: Thesis › Doctoral Thesis

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Abstract

HIV-induced dysfunction of B-cells and antibody production may contribute to impaired control of HIV replication. One mechanism by which HIV may evade protective antibody responses is to reduce opsonophagocytic antibody responses against HIV antigens by impairing memory B-cell isotype switching to lgG2 antibody production. This would also have the effect of increasing susceptibility to infection by pneumococci and other encapsulated bacteria. This thesis addresses the impact of B-cell and follicular-helper (T_FH) cell depletion and dysfunction on switching of pneumococcal polysaccharide antibodies to lgG2 in HIV-1Infection.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Fernandez, Sonia, Supervisor French, Martyn, Supervisor
Award date	19 Aug 2016
Publication status	Unpublished - 2015

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THESIS - DOCTOR OF PHILOSOPHY - ABUDULAI Naamah Laila - 2015
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Cite this

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title = "Impaired memory B cell IgG isotype switching and circulating T follicular-helper cell dysfunction in patients with chronic HIV-1 infection",

abstract = "HIV-induced dysfunction of B-cells and antibody production may contribute to impaired control of HIV replication. One mechanism by which HIV may evade protective antibody responses is to reduce opsonophagocytic antibody responses against HIV antigens by impairing memory B-cell isotype switching to lgG2 antibody production. This would also have the effect of increasing susceptibility to infection by pneumococci and other encapsulated bacteria. This thesis addresses the impact of B-cell and follicular-helper (TFH) cell depletion and dysfunction on switching of pneumococcal polysaccharide antibodies to lgG2 in HIV-1Infection.",

keywords = "T follicular cells, IgG2 antibodies, Isotype switching, HIV-1 infection, B cells, Pneumococcal infection, Opsonophagocytic antibody",

author = "Abudulai, {Naamah Laila}",

year = "2015",

language = "English",

school = "The University of Western Australia",

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TY - BOOK

T1 - Impaired memory B cell IgG isotype switching and circulating T follicular-helper cell dysfunction in patients with chronic HIV-1 infection

AU - Abudulai, Naamah Laila

PY - 2015

Y1 - 2015

N2 - HIV-induced dysfunction of B-cells and antibody production may contribute to impaired control of HIV replication. One mechanism by which HIV may evade protective antibody responses is to reduce opsonophagocytic antibody responses against HIV antigens by impairing memory B-cell isotype switching to lgG2 antibody production. This would also have the effect of increasing susceptibility to infection by pneumococci and other encapsulated bacteria. This thesis addresses the impact of B-cell and follicular-helper (TFH) cell depletion and dysfunction on switching of pneumococcal polysaccharide antibodies to lgG2 in HIV-1Infection.

AB - HIV-induced dysfunction of B-cells and antibody production may contribute to impaired control of HIV replication. One mechanism by which HIV may evade protective antibody responses is to reduce opsonophagocytic antibody responses against HIV antigens by impairing memory B-cell isotype switching to lgG2 antibody production. This would also have the effect of increasing susceptibility to infection by pneumococci and other encapsulated bacteria. This thesis addresses the impact of B-cell and follicular-helper (TFH) cell depletion and dysfunction on switching of pneumococcal polysaccharide antibodies to lgG2 in HIV-1Infection.

KW - T follicular cells

KW - IgG2 antibodies

KW - Isotype switching

KW - HIV-1 infection

KW - B cells

KW - Pneumococcal infection

KW - Opsonophagocytic antibody

M3 - Doctoral Thesis

ER -

Impaired memory B cell IgG isotype switching and circulating T follicular-helper cell dysfunction in patients with chronic HIV-1 infection

Abstract

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