Impaired endothelium-dependent and independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: role of dyslipidaemia

Gerald Watts, S.F. O'Brien, W. Silvester, J.A. Millar

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

1. We measured endothelium-dependent and independent dilatation of forearm resistance arteries in 29 men with diet-treated non-insulin-dependent diabetes mellitus and 18 age- and sex-matched control subjects, None of the diabetic patients had hypercholesterolaemia, overt hypertension or microproteinuria.2. We examined endogenous and exogenous nitric oxide-mediated vasodilatation by measuring forearm blood how with venous occlusive plethysmography after administration of acetylcholine (7.5 and 15 mu g/min) and sodium nitroprusside (3 and 10 mu g/min), respectively, into the brachial artery, N-G-monomethyl-L-arginine was also infused to study the inhibition of basal and stimulated release of nitric oxide.3. The vasodilatory response to acetylcholine, expressed as area under curve, was significantly decreased in the diabetic patients compared with the control subjects (P=0.019). N-G-monomethyl-L-arginine significantly reduced basal (P
Original languageEnglish
Pages (from-to)567-573
JournalClinical Science
Volume91
Issue numberN/A
Publication statusPublished - 1996

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