Impacts of exercise on platelet and vascular function in humans

Research output: ThesisDoctoral Thesis

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Abstract

The studies in this thesis provided novel mechanistic insight into the "exercise paradox" in humans. We observed that some forms of acute exercise can exacerbate platelet activation, whereas some forms of chronic exercise training may prevent time­ dependent Increases In monocyte-platelet aggregation. These findings provide an important reminder that acute coronary events and ischaemic stroke, the principal causes of worldwide mortality and morbidity, are not only related to impaired function of the vessel wall, but also to the function of circulating platelets and, ultimately, to the dynamic interaction between components in circulating blood and the inner lining of the vessel wall.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date7 Jul 2017
DOIs
Publication statusUnpublished - 2017

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