Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

P. Chruściel, Amirhossein Sahebkar, M. Rembek-Wieliczko, M.C. Serban, S. Ursoniu, D.P. Mikhailidis, S.R. Jones, S. Mosteoru, M.J. Blaha, S.S. Martin, J. Rysz, P.P. Toth, G.Y.H. Lip, M.J. Pencina, K.K. Ray, M. Banach

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    Abstract

    © 2016 Elsevier Ireland LtdBackground and aims The effect of statin therapy on plasma adiponectin levels has not been conclusively studied. Therefore, we aimed to evaluate this effect through a systematic review and meta-analysis of available randomized controlled trials (RCTs). Methods Quantitative data synthesis was performed using a random-effects model with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Results In 30 studies (43 study arms) with 2953 participants, a significant increase in plasma adiponectin levels was observed after statin therapy (WMD: 0.57 µg/mL, 95% CI: 0.18, 0.95, p = 0.004). In subgroup analysis, atorvastatin, simvastatin, rosuvastatin, pravastatin and pitavastatin were found to change plasma adiponectin concentrations by 0.70 µg/mL (95% CI: -0.26, 1.65), 0.50 µg/mL (95% CI: -0.44, 1.45), -0.70 µg/mL (95% CI: -1.08, -0.33), 0.62 µg/mL (95% CI: -0.12, 1.35), and 0.51 µg/mL (95% CI: 0.30, 0.72), respectively. With respect to duration of treatment, there was a significant increase in the subset of trials lasting =12 weeks (WMD: 0.88 µg/mL, 95% CI: 0.19, 1.57, p = 0.012) but not in the subset of
    Original languageEnglish
    Pages (from-to)194-208
    JournalAtherosclerosis
    Volume253
    DOIs
    Publication statusPublished - 2016

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    Chruściel, P., Sahebkar, A., Rembek-Wieliczko, M., Serban, M. C., Ursoniu, S., Mikhailidis, D. P., Jones, S. R., Mosteoru, S., Blaha, M. J., Martin, S. S., Rysz, J., Toth, P. P., Lip, G. Y. H., Pencina, M. J., Ray, K. K., & Banach, M. (2016). Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms. Atherosclerosis, 253, 194-208. https://doi.org/10.1016/j.atherosclerosis.2016.07.897