Impact of Shear Rate Modulation on Vascular Function in Humans

T.M. Tinken; D.H.J. Thijssen; N. Hopkins; M.A. Black; E.A. Dawson; C.T. Minson; S.C. Newcomer; M.H. Laughlin; N.T. Cable; Daniel Green

doi:10.1161/HYPERTENSIONAHA.109.134361

Impact of Shear Rate Modulation on Vascular Function in Humans

T.M. Tinken, D.H.J. Thijssen, N. Hopkins, M.A. Black, E.A. Dawson, C.T. Minson, S.C. Newcomer, M.H. Laughlin, N.T. Cable, Daniel Green

Research output: Contribution to journal › Article › peer-review

254 Citations (Scopus)

Abstract

Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow-mediated dilation, a largely NO-mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling, and bilateral handgrip exercise. During each intervention, a cuff inflated to 60 mm Hg was placed on 1 arm to unilaterally manipulate the shear rate stimulus. In the noncuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P

Original language	English
Pages (from-to)	278-285
Journal	Hypertension
Volume	54
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.109.134361
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/HYPERTENSIONAHA.109.134361

Cite this

@article{b644b753c672432a9bf3aefdb75e4ac0,

title = "Impact of Shear Rate Modulation on Vascular Function in Humans",

abstract = "Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow-mediated dilation, a largely NO-mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling, and bilateral handgrip exercise. During each intervention, a cuff inflated to 60 mm Hg was placed on 1 arm to unilaterally manipulate the shear rate stimulus. In the noncuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P",

author = "T.M. Tinken and D.H.J. Thijssen and N. Hopkins and M.A. Black and E.A. Dawson and C.T. Minson and S.C. Newcomer and M.H. Laughlin and N.T. Cable and Daniel Green",

year = "2009",

doi = "10.1161/HYPERTENSIONAHA.109.134361",

language = "English",

volume = "54",

pages = "278--285",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Impact of Shear Rate Modulation on Vascular Function in Humans

AU - Tinken, T.M.

AU - Thijssen, D.H.J.

AU - Hopkins, N.

AU - Black, M.A.

AU - Dawson, E.A.

AU - Minson, C.T.

AU - Newcomer, S.C.

AU - Laughlin, M.H.

AU - Cable, N.T.

AU - Green, Daniel

PY - 2009

Y1 - 2009

N2 - Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow-mediated dilation, a largely NO-mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling, and bilateral handgrip exercise. During each intervention, a cuff inflated to 60 mm Hg was placed on 1 arm to unilaterally manipulate the shear rate stimulus. In the noncuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P

AB - Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow-mediated dilation, a largely NO-mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling, and bilateral handgrip exercise. During each intervention, a cuff inflated to 60 mm Hg was placed on 1 arm to unilaterally manipulate the shear rate stimulus. In the noncuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P

U2 - 10.1161/HYPERTENSIONAHA.109.134361

DO - 10.1161/HYPERTENSIONAHA.109.134361

M3 - Article

SN - 0194-911X

VL - 54

SP - 278

EP - 285

JO - Hypertension

JF - Hypertension

ER -

Impact of Shear Rate Modulation on Vascular Function in Humans

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this