Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

A.C. D'Aprile; Lynette Fernandes; Paul Rigby; Roy Goldie

Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

A.C. D'Aprile, Lynette Fernandes, Paul Rigby, Roy Goldie

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P

Original language	English
Pages (from-to)	345S-348S
Journal	Clinical Science
Volume	103
Issue number	48
Publication status	Published - 2002

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title = "Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways",

abstract = "We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P",

author = "A.C. D'Aprile and Lynette Fernandes and Paul Rigby and Roy Goldie",

year = "2002",

language = "English",

volume = "103",

pages = "345S--348S",

journal = "Clinical Science",

issn = "0143-5221",

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T1 - Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

AU - D'Aprile, A.C.

AU - Fernandes, Lynette

AU - Rigby, Paul

AU - Goldie, Roy

PY - 2002

Y1 - 2002

N2 - We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P

AB - We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P

M3 - Article

SN - 0143-5221

VL - 103

SP - 345S-348S

JO - Clinical Science

JF - Clinical Science

IS - 48

ER -

Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

Abstract

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