We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P
|Publication status||Published - 2002|
D'Aprile, A. C., Fernandes, L., Rigby, P., & Goldie, R. (2002). Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways. Clinical Science, 103(48), 345S-348S.