Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

A.C. D'Aprile, Lynette Fernandes, Paul Rigby, Roy Goldie

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Abstract

We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [I-125]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n=8-12, P
Original languageEnglish
Pages (from-to)345S-348S
JournalClinical Science
Volume103
Issue number48
Publication statusPublished - 2002

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