Abstract
This thesis reveals that obesity contributes to increased demand of total knee replacement (TKR) as a treatment for primary osteoarthritis (OA) in Australia, particularly in the young and female populations. Patients classified as overweight, obesity class I & II and obesity class III received a TKR 2, 4 and 8 years earlier than patients with normal weight. Horizontal fissuring at the osteochondral interface caused by mechanical overload is a novel and unique pathological feature in obesity-related OA. These studies emphasize the significance of weight-loss strategy and will help in developing new interventions in the management of obesity-related OA.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 21 Jan 2021 |
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| Publication status | Unpublished - 2020 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - CHEN Lianzhi - 2021
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