Impact of obesity on knee Osteoarthritis: Population-based study of underlying Pathology

Lianzhi Chen

Research output: ThesisDoctoral Thesis

13 Downloads (Pure)

Abstract

This thesis reveals that obesity contributes to increased demand of total knee replacement (TKR) as a treatment for primary osteoarthritis (OA) in Australia, particularly in the young and female populations. Patients classified as overweight, obesity class I & II and obesity class III received a TKR 2, 4 and 8 years earlier than patients with normal weight. Horizontal fissuring at the osteochondral interface caused by mechanical overload is a novel and unique pathological feature in obesity-related OA. These studies emphasize the significance of weight-loss strategy and will help in developing new interventions in the management of obesity-related OA.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Zheng, Minghao, Supervisor
  • Wood, David, Supervisor
Award date21 Jan 2021
DOIs
Publication statusUnpublished - 2020

Fingerprint Dive into the research topics of 'Impact of obesity on knee Osteoarthritis: Population-based study of underlying Pathology'. Together they form a unique fingerprint.

Cite this