This thesis reveals that obesity contributes to increased demand of total knee replacement (TKR) as a treatment for primary osteoarthritis (OA) in Australia, particularly in the young and female populations. Patients classified as overweight, obesity class I & II and obesity class III received a TKR 2, 4 and 8 years earlier than patients with normal weight. Horizontal fissuring at the osteochondral interface caused by mechanical overload is a novel and unique pathological feature in obesity-related OA. These studies emphasize the significance of weight-loss strategy and will help in developing new interventions in the management of obesity-related OA.
|Qualification||Doctor of Philosophy|
|Award date||21 Jan 2021|
|Publication status||Unpublished - 2020|