Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

S. Santos, E. Voerman, P. Amiano, H. Barros, L. J. Beilin, A. Bergstrom, M-A Charles, L. Chatzi, C. Chevrier, G. P. Chrousos, E. Corpeleijn, O. Costa, N. Costet, S. Crozier, G. Devereux, M. Doyon, M. Eggesbo, M. P. Fantini, S. Farchi, F. Forastiere & 67 others V. Georgiu, K. M. Godfrey, D. Gori, V. Grote, W. Hanke, I. Hertz-Picciotto, B. Heude, M-F Hivert, D. Hryhorczuk, R-C Huang, H. Inskip, A. M. Karvonen, L. C. Kenny, B. Koletzko, L. K. Kupers, H. Lagstrom, I. Lehmann, P. Magnus, R. Majewska, J. Makela, Y. Manios, F. M. McAuliffe, S. W. McDonald, J. Mehegan, E. Melen, M. Mommers, C. S. Morgen, G. Moschonis, D. Murray, C. Ni Chaoimh, E. A. Nohr, A-M Nybo Andersen, E. Oken, A. J. J. M. Oostvogels, A. Pac, E. Papadopoulou, J. Pekkanen, C. Pizzi, K. Polanska, D. Porta, L. Richiardi, S. L. Rifas-Shiman, N. Roeleveld, L. Ronfani, A. C. Santos, M. Standl, H. Stigum, C. Stoltenberg, E. Thiering, C. Thijs, M. Torrent, S. C. Tough, T. Trnovec, S. Turner, M. M. H. J. van Gelder, L. van Rossem, A. von Berg, M. Vrijheid, T. G. M. Vrijkotte, J. West, A. H. Wijga, J. Wright, O. Zvinchuk, T. I. A. Sorensen, D. A. Lawlor, R. Gaillard, V. W. V. Jaddoe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.

Original languageEnglish
Pages (from-to)984-995
Number of pages12
JournalBjog-an International Journal of Obstetrics and Gynaecology
Volume126
Issue number8
DOIs
Publication statusPublished - Jul 2019

Cite this

Santos, S. ; Voerman, E. ; Amiano, P. ; Barros, H. ; Beilin, L. J. ; Bergstrom, A. ; Charles, M-A ; Chatzi, L. ; Chevrier, C. ; Chrousos, G. P. ; Corpeleijn, E. ; Costa, O. ; Costet, N. ; Crozier, S. ; Devereux, G. ; Doyon, M. ; Eggesbo, M. ; Fantini, M. P. ; Farchi, S. ; Forastiere, F. ; Georgiu, V. ; Godfrey, K. M. ; Gori, D. ; Grote, V. ; Hanke, W. ; Hertz-Picciotto, I. ; Heude, B. ; Hivert, M-F ; Hryhorczuk, D. ; Huang, R-C ; Inskip, H. ; Karvonen, A. M. ; Kenny, L. C. ; Koletzko, B. ; Kupers, L. K. ; Lagstrom, H. ; Lehmann, I. ; Magnus, P. ; Majewska, R. ; Makela, J. ; Manios, Y. ; McAuliffe, F. M. ; McDonald, S. W. ; Mehegan, J. ; Melen, E. ; Mommers, M. ; Morgen, C. S. ; Moschonis, G. ; Murray, D. ; Ni Chaoimh, C. ; Nohr, E. A. ; Andersen, A-M Nybo ; Oken, E. ; Oostvogels, A. J. J. M. ; Pac, A. ; Papadopoulou, E. ; Pekkanen, J. ; Pizzi, C. ; Polanska, K. ; Porta, D. ; Richiardi, L. ; Rifas-Shiman, S. L. ; Roeleveld, N. ; Ronfani, L. ; Santos, A. C. ; Standl, M. ; Stigum, H. ; Stoltenberg, C. ; Thiering, E. ; Thijs, C. ; Torrent, M. ; Tough, S. C. ; Trnovec, T. ; Turner, S. ; van Gelder, M. M. H. J. ; van Rossem, L. ; von Berg, A. ; Vrijheid, M. ; Vrijkotte, T. G. M. ; West, J. ; Wijga, A. H. ; Wright, J. ; Zvinchuk, O. ; Sorensen, T. I. A. ; Lawlor, D. A. ; Gaillard, R. ; Jaddoe, V. W. V. / Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts. In: Bjog-an International Journal of Obstetrics and Gynaecology. 2019 ; Vol. 126, No. 8. pp. 984-995.
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title = "Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts",
abstract = "Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95{\%} CI 2.31- 2.74). We estimated that 23.9{\%} of any pregnancy complication was attributable to maternal overweight/obesity and 31.6{\%} of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.",
keywords = "Birthweight, body mass index, pregnancy complications, preterm birth, weight gain, DIABETES-MELLITUS, PRETERM BIRTH, OBESITY, RISK, ASSOCIATION, OUTCOMES, EPIDEMIOLOGY, DISEASE",
author = "S. Santos and E. Voerman and P. Amiano and H. Barros and Beilin, {L. J.} and A. Bergstrom and M-A Charles and L. Chatzi and C. Chevrier and Chrousos, {G. P.} and E. Corpeleijn and O. Costa and N. Costet and S. Crozier and G. Devereux and M. Doyon and M. Eggesbo and Fantini, {M. P.} and S. Farchi and F. Forastiere and V. Georgiu and Godfrey, {K. M.} and D. Gori and V. Grote and W. Hanke and I. Hertz-Picciotto and B. Heude and M-F Hivert and D. Hryhorczuk and R-C Huang and H. Inskip and Karvonen, {A. M.} and Kenny, {L. C.} and B. Koletzko and Kupers, {L. K.} and H. Lagstrom and I. Lehmann and P. Magnus and R. Majewska and J. Makela and Y. Manios and McAuliffe, {F. M.} and McDonald, {S. W.} and J. Mehegan and E. Melen and M. Mommers and Morgen, {C. S.} and G. Moschonis and D. Murray and {Ni Chaoimh}, C. and Nohr, {E. A.} and Andersen, {A-M Nybo} and E. Oken and Oostvogels, {A. J. J. M.} and A. Pac and E. Papadopoulou and J. Pekkanen and C. Pizzi and K. Polanska and D. Porta and L. Richiardi and Rifas-Shiman, {S. L.} and N. Roeleveld and L. Ronfani and Santos, {A. C.} and M. Standl and H. Stigum and C. Stoltenberg and E. Thiering and C. Thijs and M. Torrent and Tough, {S. C.} and T. Trnovec and S. Turner and {van Gelder}, {M. M. H. J.} and {van Rossem}, L. and {von Berg}, A. and M. Vrijheid and Vrijkotte, {T. G. M.} and J. West and Wijga, {A. H.} and J. Wright and O. Zvinchuk and Sorensen, {T. I. A.} and Lawlor, {D. A.} and R. Gaillard and Jaddoe, {V. W. V.}",
year = "2019",
month = "7",
doi = "10.1111/1471-0528.15661",
language = "English",
volume = "126",
pages = "984--995",
journal = "BJOG: an International Journal of Obstetrics and Gynecology",
issn = "1470-0328",
publisher = "John Wiley & Sons",
number = "8",

}

Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, LJ, Bergstrom, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, M-F, Hryhorczuk, D, Huang, R-C, Inskip, H, Karvonen, AM, Kenny, LC, Koletzko, B, Kupers, LK, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Melen, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Ni Chaoimh, C, Nohr, EA, Andersen, A-MN, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Ronfani, L, Santos, AC, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, van Gelder, MMHJ, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, AH, Wright, J, Zvinchuk, O, Sorensen, TIA, Lawlor, DA, Gaillard, R & Jaddoe, VWV 2019, 'Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts' Bjog-an International Journal of Obstetrics and Gynaecology, vol. 126, no. 8, pp. 984-995. https://doi.org/10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts. / Santos, S.; Voerman, E.; Amiano, P.; Barros, H.; Beilin, L. J.; Bergstrom, A.; Charles, M-A; Chatzi, L.; Chevrier, C.; Chrousos, G. P.; Corpeleijn, E.; Costa, O.; Costet, N.; Crozier, S.; Devereux, G.; Doyon, M.; Eggesbo, M.; Fantini, M. P.; Farchi, S.; Forastiere, F.; Georgiu, V.; Godfrey, K. M.; Gori, D.; Grote, V.; Hanke, W.; Hertz-Picciotto, I.; Heude, B.; Hivert, M-F; Hryhorczuk, D.; Huang, R-C; Inskip, H.; Karvonen, A. M.; Kenny, L. C.; Koletzko, B.; Kupers, L. K.; Lagstrom, H.; Lehmann, I.; Magnus, P.; Majewska, R.; Makela, J.; Manios, Y.; McAuliffe, F. M.; McDonald, S. W.; Mehegan, J.; Melen, E.; Mommers, M.; Morgen, C. S.; Moschonis, G.; Murray, D.; Ni Chaoimh, C.; Nohr, E. A.; Andersen, A-M Nybo; Oken, E.; Oostvogels, A. J. J. M.; Pac, A.; Papadopoulou, E.; Pekkanen, J.; Pizzi, C.; Polanska, K.; Porta, D.; Richiardi, L.; Rifas-Shiman, S. L.; Roeleveld, N.; Ronfani, L.; Santos, A. C.; Standl, M.; Stigum, H.; Stoltenberg, C.; Thiering, E.; Thijs, C.; Torrent, M.; Tough, S. C.; Trnovec, T.; Turner, S.; van Gelder, M. M. H. J.; van Rossem, L.; von Berg, A.; Vrijheid, M.; Vrijkotte, T. G. M.; West, J.; Wijga, A. H.; Wright, J.; Zvinchuk, O.; Sorensen, T. I. A.; Lawlor, D. A.; Gaillard, R.; Jaddoe, V. W. V.

In: Bjog-an International Journal of Obstetrics and Gynaecology, Vol. 126, No. 8, 07.2019, p. 984-995.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of maternal body mass index and gestational weight gain on pregnancy complications

T2 - an individual participant data meta-analysis of European, North American and Australian cohorts

AU - Santos, S.

AU - Voerman, E.

AU - Amiano, P.

AU - Barros, H.

AU - Beilin, L. J.

AU - Bergstrom, A.

AU - Charles, M-A

AU - Chatzi, L.

AU - Chevrier, C.

AU - Chrousos, G. P.

AU - Corpeleijn, E.

AU - Costa, O.

AU - Costet, N.

AU - Crozier, S.

AU - Devereux, G.

AU - Doyon, M.

AU - Eggesbo, M.

AU - Fantini, M. P.

AU - Farchi, S.

AU - Forastiere, F.

AU - Georgiu, V.

AU - Godfrey, K. M.

AU - Gori, D.

AU - Grote, V.

AU - Hanke, W.

AU - Hertz-Picciotto, I.

AU - Heude, B.

AU - Hivert, M-F

AU - Hryhorczuk, D.

AU - Huang, R-C

AU - Inskip, H.

AU - Karvonen, A. M.

AU - Kenny, L. C.

AU - Koletzko, B.

AU - Kupers, L. K.

AU - Lagstrom, H.

AU - Lehmann, I.

AU - Magnus, P.

AU - Majewska, R.

AU - Makela, J.

AU - Manios, Y.

AU - McAuliffe, F. M.

AU - McDonald, S. W.

AU - Mehegan, J.

AU - Melen, E.

AU - Mommers, M.

AU - Morgen, C. S.

AU - Moschonis, G.

AU - Murray, D.

AU - Ni Chaoimh, C.

AU - Nohr, E. A.

AU - Andersen, A-M Nybo

AU - Oken, E.

AU - Oostvogels, A. J. J. M.

AU - Pac, A.

AU - Papadopoulou, E.

AU - Pekkanen, J.

AU - Pizzi, C.

AU - Polanska, K.

AU - Porta, D.

AU - Richiardi, L.

AU - Rifas-Shiman, S. L.

AU - Roeleveld, N.

AU - Ronfani, L.

AU - Santos, A. C.

AU - Standl, M.

AU - Stigum, H.

AU - Stoltenberg, C.

AU - Thiering, E.

AU - Thijs, C.

AU - Torrent, M.

AU - Tough, S. C.

AU - Trnovec, T.

AU - Turner, S.

AU - van Gelder, M. M. H. J.

AU - van Rossem, L.

AU - von Berg, A.

AU - Vrijheid, M.

AU - Vrijkotte, T. G. M.

AU - West, J.

AU - Wijga, A. H.

AU - Wright, J.

AU - Zvinchuk, O.

AU - Sorensen, T. I. A.

AU - Lawlor, D. A.

AU - Gaillard, R.

AU - Jaddoe, V. W. V.

PY - 2019/7

Y1 - 2019/7

N2 - Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.

AB - Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.

KW - Birthweight

KW - body mass index

KW - pregnancy complications

KW - preterm birth

KW - weight gain

KW - DIABETES-MELLITUS

KW - PRETERM BIRTH

KW - OBESITY

KW - RISK

KW - ASSOCIATION

KW - OUTCOMES

KW - EPIDEMIOLOGY

KW - DISEASE

U2 - 10.1111/1471-0528.15661

DO - 10.1111/1471-0528.15661

M3 - Article

VL - 126

SP - 984

EP - 995

JO - BJOG: an International Journal of Obstetrics and Gynecology

JF - BJOG: an International Journal of Obstetrics and Gynecology

SN - 1470-0328

IS - 8

ER -