TY - JOUR
T1 - Impact of intraabdominal hypertension on kidney failure in critically ill patients
T2 - A post-hoc database analysis
AU - on behalf of the IROI and iSOFA Study Investigators
AU - Bachmann, Kaspar F.
AU - Regli, Adrian
AU - Mändul, Merli
AU - Davis, Wendy
AU - Reintam Blaser, Annika
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/10
Y1 - 2022/10
N2 - Purpose: To assess whether intraabdominal hypertension (IAH) may influence kidney failure as well as mortality. Methods: This post-hoc analysis of two databases (IROI and iSOFA study) tested the independent association between IAH and kidney failure. Mortality was assessed using four prespecified groups (IAH present, kidney failure present, IAH and kidney failure present and no IAH or kidney failure present). Results: Of 825 critically ill patients, 302 (36.6%) developed kidney failure and 192 (23.7%) died during the first 90 days. Only ‘Cumulative days with IAH grade II or more’ was significantly associated with kidney failure (OR 1.29 (1.08–1.55), p = 0.003) while ‘cumulative days with IAH grade I or more’ (p = 0.135) or highest daily IAP (p = 0.062) was not. IAH combined with kidney failure was independently associated with 90-day mortality (OR 2.20 (1.20–4.05), p = 0.011), which was confirmed for higher grades of IAH (grade II or more) alone (OR 2.14 (1.07–4.30), p = 0.032) and combined with kidney failure (OR 3.25 (1.72–6.12), p < 0.001). Conclusions: This study suggest that duration as well as higher grades of IAH are associated with kidney failure and may increase mortality.
AB - Purpose: To assess whether intraabdominal hypertension (IAH) may influence kidney failure as well as mortality. Methods: This post-hoc analysis of two databases (IROI and iSOFA study) tested the independent association between IAH and kidney failure. Mortality was assessed using four prespecified groups (IAH present, kidney failure present, IAH and kidney failure present and no IAH or kidney failure present). Results: Of 825 critically ill patients, 302 (36.6%) developed kidney failure and 192 (23.7%) died during the first 90 days. Only ‘Cumulative days with IAH grade II or more’ was significantly associated with kidney failure (OR 1.29 (1.08–1.55), p = 0.003) while ‘cumulative days with IAH grade I or more’ (p = 0.135) or highest daily IAP (p = 0.062) was not. IAH combined with kidney failure was independently associated with 90-day mortality (OR 2.20 (1.20–4.05), p = 0.011), which was confirmed for higher grades of IAH (grade II or more) alone (OR 2.14 (1.07–4.30), p = 0.032) and combined with kidney failure (OR 3.25 (1.72–6.12), p < 0.001). Conclusions: This study suggest that duration as well as higher grades of IAH are associated with kidney failure and may increase mortality.
KW - Acute kidney injury
KW - Intraabdominal hypertension
KW - Intraabdominal pressure
KW - Kidney dysfunction
KW - Mortality
KW - Outcome
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=85132745668&partnerID=8YFLogxK
U2 - 10.1016/j.jcrc.2022.154078
DO - 10.1016/j.jcrc.2022.154078
M3 - Article
C2 - 35738182
AN - SCOPUS:85132745668
SN - 0883-9441
VL - 71
JO - Journal of Critical Care
JF - Journal of Critical Care
M1 - 154078
ER -