Impact of inhaled glucocorticoids on early postnatal lung development

Jana Kovar

    Research output: ThesisDoctoral Thesis

    55 Downloads (Pure)

    Abstract

    [Truncated] Introduction: The use of inhaled glucocorticoids in children during the first two years of life is controversial and poses concern given that the lung is thought to undergo major structural remodeling during this time. There is evidence in animal models that the administration of systemic glucocorticoids during this phase of early postnatal lung maturation, leads to severe and irreversible impairment of alveolar development.
    Aims: The aims of this thesis are to investigate the impact of inhaled glucocorticoids on early postnatal lung development, examining both structure and function, using the rabbit as a model.
    Hypotheses: The main hypotheses are that chronic exposure to inhaled glucocorticoids produces structural changes in the lung during early postnatal development and that these structural changes correlate with detectable changes in lung function.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    DOIs
    Publication statusUnpublished - 2002

    Take-down notice

    • This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact digitaltheses-lib@uwa.edu.au

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